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GenomicsDNA methylation variability in a pilot study group with ischemic stroke
Elevated plasma homocysteine is an independent risk factor for cardiovascular disease and stroke, however the etiology remains poorly understood. Elevated homocysteine is known to inhibit methyltransferases including DNA methyltransferases, but no methylome-wide analysis of elevated homocysteine has...
ORGANISM(S): Homo sapiens 
2014-05-27 | E-GEOD-57962 | biostudies-arrayexpress
TranscriptomicsVascular histone deacetylation by pharmacological HDAC inhibition [TSA, RNA-seq]
HDAC inhibitors are thought to regulate gene expression by post-translational modification of histone as well as non-histone proteins. Often studied at single loci, increased histone acetylation is the paradigmatic mechanism of action, however, little is known of the extent of genome-wide changes of...
ORGANISM(S): Homo sapiens 
2014-02-23 | E-GEOD-37376 | biostudies-arrayexpress
GenomicsEpigenetic regulation of cell type-specific expression patterns in the human mammary epithelium [MSDK-Seq]
Here we describe the application of high-throughput sequencing technology for profiling histone and DNA methylation, and gene expression patterns of normal human mammary progenitor-enriched and luminal lineage-committed cells. We observed significant differences in histone H3 lysine 27 tri-methylati...
ORGANISM(S): Homo sapiens 
2011-03-01 | E-GEOD-26139 | biostudies-arrayexpress
TranscriptomicsVascular histone deacetylation by pharmacological HDAC inhibition [SAHA, RNA-seq]
HDAC inhibitors are thought to regulate gene expression by post-translational modification of histone as well as non-histone proteins. Often studied at single loci, increased histone acetylation is the paradigmatic mechanism of action, however, little is known of the extent of genome-wide changes of...
ORGANISM(S): Homo sapiens 
2014-02-23 | E-GEOD-54912 | biostudies-arrayexpress
GenomicsGenome-wide analysis distinguishes hyperglycemia regulated epigenetic signatures of primary vascular cells (ChIP-seq)
We report that hyperglycemia-mediated induction of genes and pathways associated to endothelial dysfunction occur through modulation of acetylated H3K9/K14 inversely correlated with methyl-CpG content. Examination of H3K9/K14 histone acetylation and DNA methylation in hyperglycemic conditions.
ORGANISM(S): Homo sapiens 
2011-06-01 | E-GEOD-29251 | biostudies-arrayexpress
GenomicsVascular histone deacetylation by pharmacological HDAC inhibition [TSA, ChIP-seq]
HDAC inhibitors are thought to regulate gene expression by post-translational modification of histone as well as non-histone proteins. Often studied at single loci, increased histone acetylation is the paradigmatic mechanism of action, however, little is known of the extent of genome-wide changes of...
ORGANISM(S): Homo sapiens 
2014-02-23 | E-GEOD-37377 | biostudies-arrayexpress
GenomicsDeep sequencing reveals increased DNA methylation in chronic rat epilepsy (MBD-seq)
Explore DNA methylation in chronic epilepsy and its relationship to gene expression. Examination of methylation changes in pilocarpine-treated rats compared to controls and pilocarpine-treated rats on a ketogenic diet.
ORGANISM(S): Rattus norvegicus 
2013-09-09 | E-GEOD-50077 | biostudies-arrayexpress
GenomicsEtiology matters - Comparing Genomic DNA Methylation Patterns in Three Rat Models of Acquired Epilepsy (TBI – MBD-seq)
Explore DNA methylation in traumatic brain injury model of epilepsy and its relationship to gene expression. Examination of methylation changes in stimulated rats compared to sham operated animals in traumatic brain injury model of epilepsy.
ORGANISM(S): Rattus norvegicus 
2016-09-06 | E-GEOD-75119 | biostudies-arrayexpress
TranscriptomicsEtiology matters - Comparing Genomic DNA Methylation Patterns in Three Rat Models of Acquired Epilepsy (TBI – mRNA-seq)
Explore DNA methylation in traumatic brain injury model of epilepsy and its relationship to gene expression. Examination of expression changes in stimulated rats compared to sham operated animals in traumatic brain injury model of epilepsy.
ORGANISM(S): Rattus norvegicus 
2016-09-06 | E-GEOD-75120 | biostudies-arrayexpress
GenomicsVascular histone deacetylation by pharmacological HDAC inhibition [TSA, mouse, ChIP-seq]
HDAC inhibitors are thought to regulate gene expression by post-translational modification of histone as well as non-histone proteins. Often studied at single loci, increased histone acetylation is the paradigmatic mechanism of action, however, little is known of the extent of genome-wide changes of...
ORGANISM(S): Mus musculus 
2014-02-23 | E-GEOD-54910 | biostudies-arrayexpress
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