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TranscriptomicsIkaros deficient mouse thymic lymphomas
This dataset comprises expression profiles from 3 thymic lymphomas from Ikaros deficient mice (IkL/L model, see Dumortier et al, Mol. Cell. Biol. 26, 209-220, 2006 for a description of the tumor model) and 3 thymic lymphomas from IkL/L mice that harbor a mutation of the Notch1 gene (deletion of flox...
ORGANISM(S): Mus musculus 
2010-09-03 | E-GEOD-23972 | biostudies-arrayexpress
TranscriptomicsGene expression in WT and Ikaros-deficient LSK cells
The Ikaros zink finger transcription factor is a critical regulator of the hematopietic system, and plays an important role in the regulation of the development and function of several blood cell lineages. We used microarrays to characterize how Ikaros deficieny affects global transcription in the h...
ORGANISM(S): Mus musculus 
2015-11-03 | E-GEOD-61147 | biostudies-arrayexpress
TranscriptomicsWT and Ikaros-deficient follicular B cells stimulated with anti-IgM
We have observed that follicular B cells from mice with a hypomorphic mutation (IkL/L) in the Ikzf1 gene (which encodes the Ikaros transcription factor) exhibit an increased proliferative response to anti-IgM stimulation (Kirstetter et al, Eur J Immunol, 32:720-30, 2002). We asked if Ikaros controls...
ORGANISM(S): Mus musculus 
2016-01-26 | E-GEOD-75712 | biostudies-arrayexpress
GenomicsMapping of Ikaros and RBPJ binding sites in the mouse T cell leukemia cell line T29
The transcription factor Ikaros represses Notch signaling. Since Ikaros and Notch treanscriptional mediator RBPJ both recognize sequences that contain the same core TGGGAA motif, it was hypothesized that Ikaros represses Notch signaling by targeting Notch response elements and competing with RBPJ fo...
ORGANISM(S): Mus musculus 
2014-04-02 | E-GEOD-46119 | biostudies-arrayexpress
GenomicsMapping of Notch1 binding sites in a mouse immature T cell line
We used an immature mouse T cell line engineered to express a biotinylated form of the cleaved form of Notch1 (ICN1). ICN1-bound sites were precipitated with streptavidin-coated beads and subjected to ChIP-sequencing. Beko cells correspond to a spontaneous T lymphoma immature cell line derived from ...
ORGANISM(S): Mus musculus 
2014-04-02 | E-GEOD-46114 | biostudies-arrayexpress
TranscriptomicsGene expression in DN4 thymocytes from mice with an inducible deletion of Ikaros
The aim of the experiment was to visualize genes under the control of Ikaros during early T cell development. We used mice carrying floxed Ikaros alleles that were crossed with the Rosa26-CreERT2 mice, and which were injected with tamoxifen for 4 days. DN4 thymocytes were sorted from 4 mice (5-6 wee...
ORGANISM(S): Mus musculus 
2013-04-17 | E-GEOD-46093 | biostudies-arrayexpress
TranscriptomicsGene expression in double positive thymocytes from mice with CD4-Cre-mediated deletion of Ikaros
Double positive thymocytes (CD4+CD8+CD3lo) were sorted from 3-4-week old mice from Ikf/f CD4-Cre+ or Ikf/f CD4-Cre- mice (2 mice per genotype) and their transcriptome analyzed. 4 samples
ORGANISM(S): Mus musculus 
2013-04-17 | E-GEOD-46092 | biostudies-arrayexpress
TranscriptomicsGene expression in WT and Ikaros-deficient DN3, DN4 and DP thymocyte populations
DN3, DN4 and DP cells were sorted from 3-4 week old WT and mice and subjected to transcriptome analysis Cells from 3 mice were pooled for sorting.
ORGANISM(S): Mus musculus 
2013-04-17 | E-GEOD-46090 | biostudies-arrayexpress
TranscriptomicsEffect of a gamma secretase inhibitor on the T29 cell line
The mouse Ikaros-deficient thymic lymphoma cell line T29 was treated with a gamma-secretase inhibitor or vehicle (DMSO) for 36h and subjected to transcriptome analysis. 4 samples
ORGANISM(S): Mus musculus 
2013-04-17 | E-GEOD-46095 | biostudies-arrayexpress
TranscriptomicsNotch responsive genes in the T29 cell line
The mouse Ikaros-deficient thymic lymphoma cell line T29 was transduced with a retrovirus expressing an fusion protein between a dominant-negative form of Mastermind and the ligand binding domain of the estrogen receptor. Cells trreated with Ethanol or 4-hydroxy-tamoxyfen for 24h were profiled. We u...
ORGANISM(S): Mus musculus 
2013-04-17 | E-GEOD-46089 | biostudies-arrayexpress
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