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ProteomicsImmunoprecipitation and mass spectrometry (IP-MS) on KAT6A chimeras
Despite KAT6A chimeras potent oncogenic activity, the mechanisms by which KAT6A fusion proteins achieve genomic specificity and drive leukemogenesis remain poorly understood. Previous studies suggest that the leukemogenic potential of KAT6A-TIF2 depends on its chromatin-binding ability rather than i...
ORGANISM(S): Homo sapiens (Human) 
2025-08-08 | PXD061491 | Pride
Human Ip-ms. Kat6a fusion Immunoprecipitation Kat6a n-terminus 
ProteomicsThe histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA-binding winged helix domainThe histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA-binding winged helix domain
The lysine acetyltransferase KAT6A (MOZ, MYST3) belongs to the MYST family of chromatin regulators, facilitating histone acetylation. Dysregulation of KAT6A has been implicated in developmental syndromes and the onset of acute myeloid leukemia (AML). Previous work suggests that KAT6A is recruited to...
ORGANISM(S): Homo sapiens (Human) 
2023-01-14 | PXD034833 | Pride
Winged helix Histone acetylation Cpg islands Kat6a Chromatin 
ProteomicsInteraction proteins with KAT6A
Lysine acetyltransferases (KATs) catalyze the transfer of acetyl groups from acetyl-CoA to lysine residues. Our proteomic analysis revealed that KAT6A is acetylated at lysine 815 (K815), corresponding to mouse K816, in the hearts of mice fed a ketogenic diet under high blood pressure. To identify ch...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-11-03 | PXD059838 | Pride
Lysine acetyltransferase Kat6a Cardiomyocyte 
GenomicsRNA sequeqncing data of Kat6a–/–, Kat6a+/– and Kat6a+/+ E12.5 dorsal telencephalon and of Kat6a+/– and Kat6a+/+ E16.5 cortical neurons
RNA sequeqncing data of Kat6a–/–, Kat6a+/– and Kat6a+/+ E12.5 dorsal telencephalon and of Kat6a+/– and Kat6a+/+ E16.5 cortical neurons
PRJNA1302771 | ENA
TranscriptomicsRNA sequeqncing data of Kat6a–/–, Kat6a+/– and Kat6a+/+ E12.5 dorsal telencephalon and of Kat6a+/– and Kat6a+/+ E16.5 cortical neurons
Mutation of one allele of the KAT6A gene encoding the histone acetyltransferase KAT6A (MOZ, MYST3) causes Arboleda-Tham-Syndrome (ARTHS), which is characterised by developmental delay, cognitive impairment and autism-like behaviours. We used mice to examine the effects of Kat6a mutations on gene exp...
ORGANISM(S): Mus musculus 
2026-02-03 | GSE304794 | GEO
GenomicsEpigenetic profiling of cells following KAT6A CRISPR targeting
Epigenetic profiling of cells following KAT6A CRISPR targeting
PRJNA659930 | ENA
UnknownKAT6A Syndrome: genotype-phenotype correlation in 76 patients with pathogenic KAT6A variants.
Not available
S-EPMC6634310 | biostudies-literature
GenomicsChIP-seq analysis of ENL following KAT6A CRISPR targeting
ChIP-seq analysis of ENL following KAT6A CRISPR targeting
PRJNA693198 | ENA
GenomicsChIP-seq analysis of HA-KAT6A in MOLM-13 AML cells
ChIP-seq analysis of HA-KAT6A in MOLM-13 AML cells
PRJNA659932 | ENA
GenomicsExploitation of KAT6A for the treatment of PPP2R1A-mutated cancers
Exploitation of KAT6A for the treatment of PPP2R1A-mutated cancers
PRJNA1291106 | ENA
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