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ProteomicsImmunoprecipitation and mass spectrometry (IP-MS) on KAT6A chimeras
Despite KAT6A chimeras potent oncogenic activity, the mechanisms by which KAT6A fusion proteins achieve genomic specificity and drive leukemogenesis remain poorly understood. Previous studies suggest that the leukemogenic potential of KAT6A-TIF2 depends on its chromatin-binding ability rather than i...
ORGANISM(S): Homo sapiens (Human) 
2025-08-08 | PXD061491 | Pride
Human Ip-ms. Kat6a fusion Immunoprecipitation Kat6a n-terminus 
ProteomicsInteraction proteins with KAT6A
Lysine acetyltransferases (KATs) catalyze the transfer of acetyl groups from acetyl-CoA to lysine residues. Our proteomic analysis revealed that KAT6A is acetylated at lysine 815 (K815), corresponding to mouse K816, in the hearts of mice fed a ketogenic diet under high blood pressure. To identify ch...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-11-03 | PXD059838 | Pride
Lysine acetyltransferase Kat6a Cardiomyocyte 
UnknownComparison between karyotyping-FISH-reverse transcription PCR and RNA-sequencing-fusion gene identification programs in the detection of KAT6A-CREBBP in acute myeloid leukemia.
Not available
S-EPMC4010518 | biostudies-literature
UnknownKAT6A, a chromatin modifier from the 8p11-p12 amplicon is a candidate oncogene in luminal breast cancer.
Not available
S-EPMC4234874 | biostudies-literature
UnknownCase Report: Disease progression of renal cell carcinoma containing a novel putative pathogenic KAT6A::NRG1 fusion on Ipilimumab- Nivolumab immunotherapy. A case study and review of the literature.
Not available
S-EPMC9932956 | biostudies-literature
UnknownKAT6A and KAT7 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in NUP98-Rearranged Acute Myeloid Leukemia.
Not available
S-EPMC12498098 | biostudies-literature
UnknownThe small inhibitor WM-1119 effectively targets KAT6A-rearranged AML, but not KMT2A-rearranged AML, despite shared KAT6 genetic dependency.
Not available
S-EPMC11462755 | biostudies-literature
GenomicsKAT6A Chimeras Forms a Self-Reinforcing Epigenetic Module with NURF and MLL/COMPASS in AML [ChIPMNase]
KAT6A-CBP (K/C) and KAT6A-P300 (K/P) fusions are recurrent genetic alterations in acute myeloid leukemia(AML) that are associated with poor prognosis. The large size of these fusion proteins has posed challenges in developing preclinical models, limiting mechanistic studies. To address this, we empl...
ORGANISM(S): Homo sapiens 
2025-06-24 | GSE299383 | GEO
GenomicsKAT6A Chimeras Forms a Self-Reinforcing Epigenetic Module with NURF and MLL/COMPASS in AML [CUT&Run]
KAT6A-CBP (K/C) and KAT6A-P300 (K/P) fusions are recurrent genetic alterations in acute myeloid leukemia(AML) that are associated with poor prognosis. The large size of these fusion proteins has posed challenges in developing preclinical models, limiting mechanistic studies. To address this, we empl...
ORGANISM(S): Homo sapiens Mus musculus 
2025-06-24 | GSE299380 | GEO
GenomicsKAT6A Chimeras Forms a Self-Reinforcing Epigenetic Module with NURF and MLL/COMPASS in AML [ChIP-Seq]
KAT6A-CBP (K/C) and KAT6A-P300 (K/P) fusions are recurrent genetic alterations in acute myeloid leukemia(AML) that are associated with poor prognosis. The large size of these fusion proteins has posed challenges in developing preclinical models, limiting mechanistic studies. To address this, we empl...
ORGANISM(S): Mus musculus 
2025-06-24 | GSE299381 | GEO
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