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ProteomicsSynGAP variant from Japanese ALS cohort alters the recruitment of RNA binding proteins
FUS is one of the pathogenic RNA-binding proteins for amyotrophic lateral sclerosis (ALS). We previously reported that FUS stabilized SynGAP mRNA at its 3’UTR and maintained spine maturation and cognitive function in mice. To elucidate whether this mechanism could be pathogenic for ALS, we identifie...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD026586 | Pride
Ipsc Motor neuron Als Fus Syngap 
TranscriptomicsThe gene expression analysis of the spinal cord of SBMA (Spinal Bulbar Muscular Atrophy) model mice
To identify the gene expression changes that are specific to SBMA, we prepared total mRNA samples from the spinal cords of transgenic mice carrying a full-length human AR with 97 CAGs (AR-97Q), transgenic mice bearing a wild-type allele of AR with 24 CAGs (AR-24Q), and the wild-type littermates of t...
ORGANISM(S): Mus musculus 
2012-08-03 | E-GEOD-39865 | biostudies-arrayexpress
TranscriptomicsThe gene expression analysis of the spinal cord and skeletal muscle of SBMA (Spinal Bulbar Muscular Atrophy) model mice with or without pioglitazone (PG) treatment
To identify the gene expression changes by administering PG to SBMA model mice, we prepared total RNA samples from the spinal cords and skeletal muscles of transgenic mice carrying a full-length human AR with 97 CAGs (AR-97Q) that were treated with or without PG. We used AR-97Q (Line #7-8) male mice...
ORGANISM(S): Mus musculus 
2013-10-29 | E-GEOD-51807 | biostudies-arrayexpress
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