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TranscriptomicsThe coregulator, repressor of Estrogen Receptor Activity (REA), is a crucial regulator of the timing and magnitude of uterine decidualization.
Our findings establish a key role for the coregulator, Repressor of Estrogen receptor Activity (REA), in controlling the timing and magnitude of decidualization in human endometrial stromal cells in vitro and in the mouse uterus in vivo, and suggest that REA functions to synchronize uterine differen...
ORGANISM(S): Homo sapiens 
2013-04-04 | E-GEOD-42376 | biostudies-arrayexpress
TranscriptomicsGenomic Collaboration of Estrogen Receptor-α and ERK2 in Regulating Gene and Proliferation Programs
The nuclear hormone receptor, estrogen receptor-alpha (ERα), and MAP kinases both play key roles in hormone-dependent cancers, yet their interplay and the integration of their signaling inputs remain poorly understood. In these studies, we document that estrogen-occupied ERα activates and interact...
ORGANISM(S): Homo sapiens 
2011-01-10 | E-GEOD-24592 | biostudies-arrayexpress
TranscriptomicsRNA-seq data from MCF-7 cells (breast cancer model) treated with soy extracts
The MCF-7 were infected with either control adenovirus expressing B-galactosidase (Ad) or adenovirus expressing ERB (AdERbeta) for 72 h. For knockdown of the endogenous ERa in MCF-7 cells, cells were treated with siRNA for 24h (AdERbeta+SiERalpha). Then cells were treated with Veh (0.1% EtOH), 10 ...
ORGANISM(S): Homo sapiens 
2014-10-24 | E-GEOD-56066 | biostudies-arrayexpress
TranscriptomicsIdentification and functional characterization of long noncoding RNAs in breast cancer
In this study, we have integrated RNA-seq data from subcellular fractionated RNA (i.e., cytoplasm, nucleoplasm, and chromatin-associated) with GRO-seq data using a novel bioinformatics pipeline. This has yielded a comprehensive catalog of polyadenylated lncRNAs in MCF-7 cells, about half of which ha...
ORGANISM(S): Homo sapiens 
2015-07-30 | E-GEOD-63189 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array time series of human MCF7 breast cancer cells treated with estradiol
Using a chromatin immunoprecipitation-paired end diTag cloning and sequencing strategy, we mapped estrogen receptor alpha (ERalpha) binding sites in MCF-7 breast cancer cells. We identified 1,234 high confidence binding clusters of which 94% are projected to be bona fide ERalpha binding regions. Onl...
ORGANISM(S): Homo sapiens 
2009-01-09 | E-GEOD-11352 | biostudies-arrayexpress
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