Kauer M M - OmicsDI

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shRNA profiling of human Ewings sarcoma samples to produce a molecular function map of Ewinga??s Sarcoma

EWS-FLI1 is a chimeric ETS transcription factor that is, due to a chromosomal rearrangement, specifically expressed in Ewingâ€™s sarcoma family tumors (ESFT) and is thought to be the initiating event in the development of the disease. Previous genomic profiling experiments have identified a number o...

ORGANISM(S): Homo sapiens

2009-05-11 | E-GEOD-14543 | biostudies-arrayexpress

Variability in functional p53 reactivation by Prima-1Met/APR-246 in Ewing sarcoma

Though p53 mutations are rare in Ewing sarcoma, there is a strong indication that p53-mutant tumors form a particularly bad prognosis group. As such, novel treatment strategies are warranted that would specifically target and eradicate tumor cells containing mutant-p53 in this subset of ES patients....

ORGANISM(S): Homo sapiens

2013-11-12 | E-GEOD-49967 | biostudies-arrayexpress

Notch is active in Langerhans Cell Histiocytosis and confers pathognomonic features on dendritic cells.

Langerhans cell histiocytosis (LCH) is a disease characterized by the accumulation of eponymous CD1a+ Langerin+ Langerhans-cell (LC)-like dendritic cells (DC) of largely unknown origin. Here we have performed comparative transcriptome analysis of highly purified CD207+/CD1a+ Langerhans cell histiocy...

ORGANISM(S): Homo sapiens

2012-10-24 | E-GEOD-35340 | biostudies-arrayexpress

Microbial exchange at the wildlife-livestock interface: insights into microbial composition, antimicrobial resistance and virulence factor gene dynamics in grassland ecosystems.

Not available

S-EPMC12330063 | biostudies-literature

Seasonal shifts and land-use impact: unveiling the gut microbiomes of bank voles (Myodes glareolus) and common voles (Microtus arvalis).

Not available

S-EPMC11650868 | biostudies-literature

Timing Genomic Antigen Loss in Multiple Myeloma Treated with T Cell-Redirecting Immunotherapies.

Not available

S-EPMC12514755 | biostudies-literature

Hitchhiking mapping: a population-based fine-mapping strategy for adaptive mutations in Drosophilamelanogaster.