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ProteomicsIntegration of Proteomics, Phosphoproteomics and Kinomics Enables the Discovery of Anticancer Drugs for Pancreatic Cancer
Here we performed proteomic examination of surgical specimens. This lead to the prediction of a number of drugs that induced apoptosis in the patient-derived cell lines.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-06-28 | MSV000089751 | MassIVE
ProteomicsInterplay between bacterial RNA 5'-termini deNADding protein NudC and DEAD-box RNA helicase CsdA in stress-responses
Nicotinamide adenine dinucleotide (NAD) "cap" recently discovered in bacteria could have similar functions as eukaryotic 7-methylguanine (m7G) "cap", which protects RNA 5'-terminus from degradation and mediates RNA interactions with proteins involved in its transportation, editing and translation. T...
ORGANISM(S): Escherichia Coli (ncbitaxon:562) 
2022-07-10 | MSV000089861 | MassIVE
ProteomicsYeast efficiently secretes high amounts of human calreticulin without cellular stress
The ER chaperone Calreticulin (CALR) has extracellular functions and can leave the mammalian cell in response to various factors although, the mechanism of how it is carried out is unknown. Yeast Saccharomyces cerevisiae efficiently secretes CALR, and the analysis of this process in yeast could help...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-02-21 | MSV000088879 | MassIVE
ProteomicsIntegration of Proteomics, Phosphoproteomics and Kinomics Enables the Discovery of Anticancer Drugs for Pancreatic Cancer
Here we performed phosphoproteomic, kinome examination of surgical specimens and patient-derived cancer cell lines.Kinomics and phosphoproteomics identified changes in the activity of a number of identical protein kinases in PDAC tumors and tissue culture cells. This allowed us to use these kinases...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-06-27 | MSV000089736 | MassIVE
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