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TranscriptomicsFunctional Genomics Reveals Extended Roles of the Mycobacterium tuberculosis Stress Response Factor sigmaH
DNA Microarray based comparison of M. tuberculosis and its isogenic delta-sigmaH mutant for an extended period of time, using a diamide-stress and removal strategy (post-diamide stress or PDS) Raw data has been requested of, but not provided by, the submitter. Two strains, M. tuberculosis vs delta-...
ORGANISM(S): Mycobacterium tuberculosis 
2010-06-24 | E-GEOD-15608 | biostudies-arrayexpress
TranscriptomicsPlatelet Activating Factor Receptor and Innate Immunity
This data series contains spotted oligo microarray data from 10 different experiments using Agilent Rat v2 microarrays. This data is being made public in support of Fillon S et al. Journal of Immunology, (2006). Proinflammatory bacterial components are at least partially responsible for causing the ...
ORGANISM(S): Rattus norvegicus 
2010-07-01 | E-GEOD-5545 | biostudies-arrayexpress
TranscriptomicsFocused examination of the intestinal lamina propria yields greater molecular insight into mechanisms underlying SIV induced immune dysfunction
In this study three Indian rhesus macaques were infected with Simian Immunodeficiency Virus (SIVmac251). This generates a chronic infection mirroring AIDS in the animals. Prior to infection (day 0) and at two different time-points post-infection (day 21 and day 90), intestinal resection biopsies wer...
ORGANISM(S): Macaca mulatta 
2011-12-10 | E-GEOD-34300 | biostudies-arrayexpress
TranscriptomicsMycobacterium tuberculosis gene expression in response to thioridazine (THZ)
The gene expression profiles of Mtb after treatment at the minimal inhibitory concentration (MIC) or 4 X MIC at an early stage (up to 6 hours) was compared to untreated Mtb. Our experiment is designed to in order to ensure that the primary effects (0-6h) of the drugs and any dose (1X MIC and 4X MIC)...
ORGANISM(S): Mycobacterium tuberculosis 
2010-05-16 | E-GEOD-16626 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse bone marrow macrophages from IL-6-/- and IL-10-/- mutants treated with IL-10 or IL-6 stimulation in the presence of LPS
IL-10 or IL-6 stimulation of control 129xC57BL/6 murine bone marrow derived macrophages in the presence of LPS. We used microarrays to detail the global programme of gene expression changes in response to IL-6 or IL-10 stimulation in the presence of lipopolysaccharide. BMDMs were isolated from cont...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5589 | biostudies-arrayexpress
ProteomicsMRM quantification of circulating CFP-10 in TB patients
Liquid chromatography coupled mass spectrometry (LC-MS) operating in targeted mass spectrometry (MS) including multiple reaction monitoring (MRM) mode is an accurate analytical method. Integrating with nanoelectrospray-tandem MS (NanoES-MS/MS) and immunoprecipitation (IP), it becomes a promising met...
ORGANISM(S): Mycobacterium Tuberculosis 
2022-04-14 | PXD021150 | panorama
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