Sort   by:  
 Page size 
ProteomicsAP-MS of small molecule that selectively destabilizes Cryptochrome 1
Cryptochromes are negative transcriptional regulators of the circadian clock in mammals. It is not clear how reducing the level of endogenous CRY1 in mammals will affect circadian rhythm and the relation of such a decrease with apoptosis. Here, we discovered a molecule (M47) that destabilizes Cryp...
ORGANISM(S): Homo sapiens (Human) 
2022-11-07 | PXD037311 | Pride
Ap-ms Mouse Small molecule 
MetabolomicsClock regulation of metabolites reveals coupling between transcription and metabolism
The circadian clock is intricately connected with metabolism, however the precise details of these connections are incomplete. Here we used high temporal resolution metabolite profiling to determine circadian regulation of mouse liver and cell autonomous metabolism. In mouse liver, we found ~50% of ...
2017-04-05 | MTBLS292 | MetaboLights
Sort   by:  
 Page size