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ProteomicsInhibition of T cell activation and function by the CIN85 adaptor protein
CIN85 is ubiquitously expressed adaptor protein. In T cells, CIN85 is recruited to the TCR signaling complex and inhibit TCR signaling. To reveal the molecular function of CIN85-mediated inhibition, we performed Flag-CIN85 (CIN85dA) immuno-precipitation and identified the binding proteins. As a nega...
ORGANISM(S): Mus Musculus (mouse) 
2019-01-16 | PXD012369 | JPOST Repository
ProteomicsProteomic Profiling of HEK293-F cell and human peripheral blood neutrophil proteins extracted by conventional direct extraction and phenol-guanidinium isothiocyanate (P/GTC)-based extraction methods
To evaluate the performance of the phenol-guanidinium isothiocyanate (P/GTC)-based extraction method in proteomic analysis, we performed proteome analysis from HEK293-F cell and human peripheral blood neutrophil proteins extracted by the P/GTC-based extraction and conventional direct extraction meth...
ORGANISM(S): Homo Sapiens (human) 
2019-10-28 | PXD011487 | JPOST Repository
UnknownCorrelation Between Lateralization Index of Adrenal Venous Sampling and Standardized Outcome in Primary Aldosteronism.
Not available
S-EPMC6057509 | biostudies-literature
TranscriptomicsAccumulated α-synuclein affects the progression of GM2 gangliosidoses
The accumulation of α-synuclein (ASyn) has been observed in several lysosomal storage diseases (LSD), but it remains unclear if the accumulation of ASyn contributes to the pathology. The mitochondria degeneration, reduced expression of manganese superoxide dismutase 2, and reactive oxygen species-me...
ORGANISM(S): Mus musculus 
2015-05-12 | E-GEOD-68748 | biostudies-arrayexpress
ProteomicsDIA-MS based plasma peptidomics workflow for profiling organ-derived peptides
In this study, we acquired DDA-MS data and DIA-MS data from peptide extracts of plasma and eleven organs (lung, spleen, adrenal gland, kidney, heart, liver, muscle, pancreas, cerebellum, hippocampus, and cerebral cortex). These data were analyzed using FragPipe v23 to obtain peptide identification r...
ORGANISM(S): Mus Musculus (mouse) 
2026-07-13 | PXD073758 | JPOST Repository
ProteomicsSKP1A-mediated degradation of PRC2 triggers activation of Polycomb-silenced genes
Polycomb group (PcG) proteins are evolutionarily conserved repressors of developmental genes. Paradoxically, the same PcG proteins also play roles in gene activation via mechanisms that are not yet fully understood. Here, to reveal the function of S-phase kinase-associated protein 1A (SKP1A), an ess...
ORGANISM(S): Mus Musculus (mouse) 
2025-08-27 | PXD047552 | JPOST Repository
ProteomicsSKP1A-mediated degradation of PRC2 triggers activation of Polycomb-silenced genes
Polycomb group (PcG) proteins are evolutionarily conserved repressors of developmental genes. Paradoxically, the same PcG proteins also play roles in gene activation via mechanisms that are not yet fully understood. Here, to reveal the function of S-phase kinase-associated protein 1A (SKP1A), an ess...
ORGANISM(S): Mus Musculus (mouse) 
2025-08-27 | PXD047556 | JPOST Repository
UnknownCommunity-Level Compact City Design, Health Care Provision, and Outcomes of Patients With Stroke.
Not available
S-EPMC12449981 | biostudies-literature
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