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GenomicsKDM2B binds CpG islands and modulates recruitment of Ring1b
CpG island elements are associated with most mammalian gene promoters, yet how they contribute to gene regulation remains poorly understood. Recently it has become clear that a subset of CpG islands in embryonic stem cells can act as polycomb response elements and are recognized by the polycomb sile...
ORGANISM(S): Mus musculus 
2012-12-26 | E-GEOD-40860 | biostudies-arrayexpress
TranscriptomicsKdm2b facilitates iPS (induced pluripotent stem cells) cell generation
RNA samples were extracted from mouse embryonic fibroblast transduced with Oct4, Sox2 and Klf4 (OSK) or OSK plus Kdm2b at post-transduction day 4, 8 and 12.
ORGANISM(S): Mus musculus 
2012-04-22 | E-MEXP-3433 | biostudies-arrayexpress
TranscriptomicsGene expression changes following knockdown of Kdm2b on mESCs
In order to study the effects of Kdm2b binding at CpG islands, Kdm2b was knocked down in mouse embryonic stem cells using shRNA and gene expression profiled using Affymetrix arrays Depletion of KDM2B affects the gene expression of a subset of polycomb targets RNA from 4 samples stably expressing shK...
ORGANISM(S): Mus musculus 
2012-12-26 | E-GEOD-40701 | biostudies-arrayexpress
GenomicsRole of the histone demethylase KDM2B in hematopoietic homeostasis and malignancies [ChIP-seq]
Development of the hematopoietic system is dynamically controlled by the interplay of transcriptional and epigenetic networks to determine cellular identity. Those networks are critical for homeostasis and frequently dysregulated in leukemias. We identified histone demethylase Kdm2b as a critical re...
ORGANISM(S): Homo sapiens 
2016-02-22 | E-GEOD-70624 | biostudies-arrayexpress
TranscriptomicsDeletion of KDM2B DNA-binding domain affects RING1B and SUZ12 occupancy
The histone lysine demethylase protein, KDM2B, associates with the PCGF1/PRC1 complex and binds to non-methylated DNA through its ZF-CxxC domain, providing a possible molecular link between CpG island elements and polycomb nucleation (Farcas et al., 2012, Wu et al., 2013). Here, a novel genetic syst...
ORGANISM(S): Mus musculus 
2014-05-27 | E-GEOD-52619 | biostudies-arrayexpress
TranscriptomicsRole of the histone demethylase KDM2B in hematopoietic homeostasis and malignancies [human cell line gene expression]
Development of the hematopoietic system is dynamically controlled by the interplay of transcriptional and epigenetic networks to determine cellular identity. Those networks are critical for homeostasis and frequently dysregulated in leukemias. We identified histone demethylase Kdm2b as a critical re...
ORGANISM(S): Homo sapiens 
2016-02-22 | E-GEOD-74959 | biostudies-arrayexpress
TranscriptomicsRole of the histone demethylase KDM2B in hematopoietic homeostasis and malignancies [RNA-seq]
Development of the hematopoietic system is dynamically controlled by the interplay of transcriptional and epigenetic networks to determine cellular identity. Those networks are critical for homeostasis and frequently dysregulated in leukemias. We identified histone demethylase Kdm2b as a critical re...
ORGANISM(S): Mus musculus 
2016-02-22 | E-GEOD-70728 | biostudies-arrayexpress
TranscriptomicsRole of the histone demethylase KDM2B in hematopoietic homeostasis and malignancies [Kras background mouse gene expression]
Development of the hematopoietic system is dynamically controlled by the interplay of transcriptional and epigenetic networks to determine cellular identity. Those networks are critical for homeostasis and frequently dysregulated in leukemias. We identified histone demethylase Kdm2b as a critical re...
ORGANISM(S): Mus musculus 
2016-02-22 | E-GEOD-74960 | biostudies-arrayexpress
TranscriptomicsKDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2012-12-26 | E-GEOD-41267 | biostudies-arrayexpress
TranscriptomicsKdm2b maintains murine embryonic stem cell status by recruiting PRC1 complex to CpG islands of lineage genes [Expression profiling]
Polycomb group (PcG) proteins play important roles in repressing lineage-specific genes and maintaining the undifferentiated state of mouse embryonic stem cells (mESCs). However, the mechanisms by which PcG proteins are recruited to their targets are largely unknown. Here, we show that the histone d...
ORGANISM(S): Mus musculus 
2013-02-20 | E-GEOD-41298 | biostudies-arrayexpress
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