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ProteomicsSex-specific KDM6A-HNF4A-CREBH network controls lipoprotein cholesterol metabolism and atherosclerosis via epigenetic reprograming of hepatocytes.
The project investigates how X-linked epigenetic enzyme KDM6A regulates liver cholesterol metabolism and cardiovascular disease risk. We integrate multi-omics data from human liver cell lines and tissue-specific knockout mice to dissect the interplay of transcription factors and coregulators in the ...
ORGANISM(S): Homo sapiens (Human) 
2026-03-02 | PXD074624 | Pride
Liver Atherosclerosis Kdm6a 
ProteomicsAlternative mRNA splicing controls functions of the human H3K27 demethylase UTX/KDM6A
The UTX/KDM6A gene encodes the UTX histone H3K27 demethylase, which plays an important role in mammalian development and is frequently mutated in cancers and particularly, in urothelial cancers. Using BioID technique, we explored the interactome of different UTX isoforms.
ORGANISM(S): Homo sapiens (Human) 
2024-01-28 | PXD041254 | Pride
Isoforms Kdm6a Bladder cancer 
ProteomicsLoss of KDM6A-mediated genomic instability and metabolic reprogramming regulates response to therapeutic perturbations in bladder cancer
Mutations in genes encoding critical epigenetic regulators are frequently noted in bladder cancer, however, the mechanisms by which these alterations impact the therapeutic response remain incompletely understood. Through retrospective analyses of multiple bladder cancer patient cohorts, we identifi...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-04 | PXD065234 | Pride
Kdm6a Genomic instability Metabolic reprogramming Bladder cancer 
TranscriptomicsRNA-seq of primary mouse podocytes with KDM6A overexpression against controls
We performed RNA-seq experiments (three replicates) on primary mouse podocytes that were infected with control lentivirus or KDM6A-encoding lentiviruses. RNAs were first extracted using Trizol reagent (Invitrogen, USA) according to the manufacturer’s instruction. The purified RNAs were quantified at...
ORGANISM(S): Mus musculus 
2019-03-27 | E-MTAB-7695 | biostudies-arrayexpress
ProteomicsKDM6A downregulation promotes tumor-prone cytokines expression in cancer-associated fibroblasts by activating enhancers
co-IP assays demonstrate that KDM6A is bound to WDR5, facilitating its association with the COMPASS complex and the polycomb repressive complex at the expected target loci.
ORGANISM(S): Homo Sapiens 
2024-12-04 | PXD058594 |
TranscriptomicsProtein and histone binding profiles from mouse ES cells during differentiation and after Kdm6a RNAi treatment.
Here we show binding and occupancy profiles for KDM6A, H3K27me3 and H3K4me3 to address the epigenetic regulation of a subset of Rhox genes, Rhox6 and 9, in female and male ES cells during differentiation. To further address a functional role for KDM6A in the epigenetic regulation of Rhox6 and 9, bin...
ORGANISM(S): Mus musculus 
2013-03-22 | E-GEOD-45390 | biostudies-arrayexpress
GenomicsChIP-seq on KDM6A 786O cells
ChIP-seq on KDM6A 786O cells
PRJNA1129268 | ENA
TranscriptomicsExpression data from mouse ES cells after control RNAi (scramble siRNAs) or RNAi specific for Kdm6a treatment.
To address the functional role of KDM6A in the regulation of Rhox genes, male and female mouse ES cells were transfected with a mixture of three small interfering RNA duplexes, each of which targets a different region of Kdm6a mRNA. We found that Kdm6a knockdown in mouse ES cells caused a decrease i...
ORGANISM(S): Mus musculus 
2013-03-13 | E-GEOD-45034 | biostudies-arrayexpress
GenomicsKDM6A Regulates Immunogenicity of Multiple Myeloma (ChIP-seq)
KDM6A Regulates Immunogenicity of Multiple Myeloma (ChIP-seq)
PRJNA1023291 | ENA
TranscriptomicsHaematopoietic loss of KDM6A impairs cardiac recovery in heart failure via epigenetic reprogramming of myeloid cells (scRNA Human)
Clonal haematopoiesis (CH), the expansion of blood-cell clones carrying acquired mutations, is an independent risk factor for cardiovascular disease. Although mutations in DNMT3A and TET2 are well studied, the cardiovascular consequences of KDM6A mutations remain unclear. KDM6A is an X-linked histon...
ORGANISM(S): Homo sapiens 
2026-08-27 | E-MTAB-17614 | biostudies-arrayexpress
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