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TranscriptomicsGlycemic index differences of high-fat diets modulate primarily lipid metabolism in murine adipose tissue
We previously reported that a low versus high glycemic index (GI) diet on a high fat (30% kcal fat) background (LGI and HGI, respectively) significantly retarded adverse health effects in C57BL/6J male mice. The LGI diet enhanced whole body insulin sensitivity and repressed high fat diet-induced bod...
ORGANISM(S): Mus musculus 
2011-09-12 | E-GEOD-26930 | biostudies-arrayexpress
TranscriptomicsDiet induced gene expression in rat peripheral blood mononuclear cells
Gene expression of rat peripheral blood mononuclear cells was analyzed by microarray analysis in normoweight and in diet-induced obese rats (cafeteria rats). The aim of this study was to identify genes involved in energy homeostasis that are altered in the obese state. Keywords: Dietary treatment, ...
ORGANISM(S): Rattus norvegicus 
2009-12-01 | E-GEOD-14094 | biostudies-arrayexpress
TranscriptomicsShort-term, high fat-feeding-induced changes in white adipose tissue gene expression are highly predictive for long-term changes
Using standardized, semipurified diets is a crucial factor for reproducibility of experimental nutritional studies. For the purpose of comparability and integration of research, two European consortia, Mitofood and BIOCLAIMS, proposed an AIN-93-based standard reference diet, the standardized BIOCLAI...
ORGANISM(S): Mus musculus 
2013-08-27 | E-GEOD-38337 | biostudies-arrayexpress
TranscriptomicsPeripheral blood mononuclear cells gene expression reflects adaptive response and metabolic damage associated to the intake of diets with an unbalanced proportion of macronutrients
Gene expression studies in peripheral blood mononuclear cells (PBMC) can provide knowledge that would be difficult to obtain using other types of biological samples, as these cells can reflect overall response of the body to a specific stimulus, such as diet. Here, we aimed to study the impact of su...
ORGANISM(S): Rattus norvegicus 
2015-12-07 | E-GEOD-54897 | biostudies-arrayexpress
TranscriptomicsIsocaloric intake of diets differing in macronutrient content (high protein or high fat) in adult rats indicate adverse effects as analysed by hepatic transcriptomics
Intake of high-protein (HP) diets has increased over the last years, mainly due to their popularity for body weight control. Liver is the main organ handling ingested macronutrients and it is associated with the beginning of different pathologies. We aimed to deepen our knowledge on molecular pathwa...
ORGANISM(S): Rattus norvegicus 
2017-05-02 | E-GEOD-57858 | biostudies-arrayexpress
TranscriptomicsQuercetin decreases high-fat diet induced bodyweight gain and accumulation of hepatic and circulating lipids in mice.
Dietary flavonoids are supposed to be protective against cardiovascular diseases (CVD). Elevated circulating lipid levels and hepatic lipid accumulation are known risk factors for CVD. We investigated the effects and underlying molecular mechanisms of the flavonoid quercetin on hepatic lipid metabol...
ORGANISM(S): Mus musculus 
2014-10-14 | E-GEOD-51343 | biostudies-arrayexpress
TranscriptomicsMuscle Involvement in Preservation of Metabolic Flexibility by a Combination Treatment using n-3 PUFA and Rosiglitazone in Dietary-Obese Mice
Impaired resistance to insulin, the key defect in type 2 diabetes (T2D), is associated with a low capacity to adapt fuel oxidation to fuel availability, i.e., metabolic inflexibility. The hampered metabolic adaptability triggers a further damage of insulin signaling. Since skeletal muscle is the mai...
ORGANISM(S): Mus musculus 
2012-09-07 | E-GEOD-36717 | biostudies-arrayexpress
TranscriptomicsMuscle Involvement in Preservation of Metabolic Flexibility by Treatment using n-3 PUFA or Rosiglitazone in Dietary-Obese Mice
Impaired resistance to insulin, the key defect in type 2 diabetes (T2D), is associated with a low capacity to adapt fuel oxidation to fuel availability, i.e., metabolic inflexibility. The hampered metabolic adaptability triggers a further damage of insulin signaling. Since skeletal muscle is the mai...
ORGANISM(S): Mus musculus 
2012-09-07 | E-GEOD-36716 | biostudies-arrayexpress
TranscriptomicsQuercetin induces hepatic lipid omega-oxidation and lowers serum lipid levels in mice
Elevated circulating lipid levels are known risk factors for cardiovascular diseases (CVD). In order to examine the effects of quercetin on hepatic lipid metabolism and detailed serum lipid profiles, mice received a mild-high-fat diet without (control) or with supplementation of 0.33% (w/w) querceti...
ORGANISM(S): Mus musculus 
2013-02-05 | E-GEOD-39140 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat ileum mucosa and Peyers patches in the small intestine at different time points following Salmonella infection
Time dependent effect of Salmonella infection on host gene expression in vivo in the ileum mucosa and Peyer’s patches.
ORGANISM(S): Rattus norvegicus 
2007-04-02 | E-MEXP-636 | biostudies-arrayexpress
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