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TranscriptomicsGenome?wide analysis of pre?mRNA 3' end processing reveals a decisive role of human cleavage factor I in the regulation of 3' UTR length: A-seq
Through alternative polyadenylation, human mRNAs acquire longer or shorter 3' untranslated regions, the latter typically associated with higher transcript stability and increased protein production. To understand the dynamics of polyadenylation site usage, we mapped transcriptome?wide both binding s...
ORGANISM(S): Homo sapiens 
2012-05-15 | E-GEOD-37037 | biostudies-arrayexpress
TranscriptomicsCleavage Factor Im as a key regulator of 3’ UTR length
In eukaryotes, the 3' ends of RNA polymerase II-generated transcripts are made in the majority of cases by site-specific endonucleolytic cleavage, followed by the addition of a poly(A) tail. By alternative polyadenylation, a gene can give rise to multiple mRNA isoforms that differ in the length of t...
ORGANISM(S): Homo sapiens 
2012-10-30 | E-GEOD-40137 | biostudies-arrayexpress
TranscriptomicsThe systematic shortening of 3’ UTRs has limited influence on the relative change in protein abundance in proliferating cells
Alternative polyadenylation is an important cellular mechanism that enables generation of mRNA isoforms that differ in their 3' untranslated regions (3' UTRs) and consequently in their susceptibility to miRNA and RNA binding protein mediated regulation. A dramatic change in polyadenylation site usa...
ORGANISM(S): Homo sapiens 
2014-09-25 | E-GEOD-54950 | biostudies-arrayexpress
UnknownA type IV-secretion-like system is required for conjugative DNA transport of broad-host-range plasmid pIP501 in gram-positive bacteria.
Not available
S-EPMC1899387 | biostudies-literature
TranscriptomicsGenome-wide analysis of pre-mRNA 3' end processing reveals a decisive role of human cleavage factor I in the regulation of 3' UTR length: CLIP
Through alternative polyadenylation, human mRNAs acquire longer or shorter 3' untranslated regions, the latter typically associated with higher transcript stability and increased protein production. To understand the dynamics of polyadenylation site usage, we mapped transcriptome‐wide both binding s...
ORGANISM(S): Homo sapiens 
2012-05-15 | E-GEOD-37398 | biostudies-arrayexpress
TranscriptomicsA blood based 12-miRNA signature of Alzheimer patients
We applied Next-Generation Sequencing (NGS) to miRNAs from blood samples of 48 AD (Alzheimer's Disease) patients and 22 unaffected controls, yielding a total of 140 unique mature miRNAs with significantly changed expression level. Of these, 82 were higher and 58 lower abundant in samples from AD pa...
ORGANISM(S): Homo sapiens 
2013-06-17 | E-GEOD-46579 | biostudies-arrayexpress
TranscriptomicsDetecting lung tumors from circulating microRNA profiles
We aimed to determine if lung cancer detection can be improved by circulating miRNAs as biomarkers. To this end, we collected blood of over 3000 individuals using PAXgene blood tubes. The individuals were diagnosed with lung cancer (LCa), a non-tumor lung disease (NTLD), another disease (OD) or were...
ORGANISM(S): Homo sapiens 
2020-05-19 | E-MTAB-8026 | biostudies-arrayexpress
TranscriptomicsmiRNA profiles of Wilms tumor patients and controls
Blood-borne miRNA signatures have recently been reported for various tumor diseases. Here, we compared the miRNA signature in Wilms tumor patients prior to and after preoperative chemotherapy according to the SIOP protocol 2001. We did not find a significant difference between the miRNA signatures o...
ORGANISM(S): Homo sapiens 
2013-07-22 | E-GEOD-38419 | biostudies-arrayexpress
TranscriptomicsExpression data of Arabidopsis thaliana wild-type plants and quadruple nas T-DNA insertion mutants grown under different Fe supply conditions
Essential metals such as iron are required for healthy plant growth. Fe is an important cofactor and catalytic element in many biological processes. Fe and other metals can also be toxic when present in excess. Therefore plants have mechanisms of metal homeostasis which involve coordination of metal...
ORGANISM(S): Arabidopsis thaliana 
2010-09-25 | E-GEOD-24348 | biostudies-arrayexpress
TranscriptomicsmiRNA Profiles in lung cancer patients and controls with other non-cancer lung diseases
This project analyzes plasma profiles of patients suffering from lung cancer and controls with other non-cancer lung diseases Analysis of plasma obtained from 26 patients collected at up to 8 time points and from 12 controls
ORGANISM(S): Homo sapiens 
2015-09-24 | E-GEOD-68951 | biostudies-arrayexpress
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