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UnknownEfficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine.

Background

Vaccines are needed to prevent coronavirus disease 2019 (Covid-19) and to protect persons who are at high risk for complications. The mRNA-1273 vaccine is a lipid nanoparticle-encapsulated mRNA-based vaccine that encodes the prefusion stabilized full-length spike protein of the se...
S-EPMC7787219 | biostudies-literature
UnknownGenome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder.
Post-traumatic stress disorder (PTSD) genetics are characterized by lower discoverability than most other psychiatric disorders. The contribution to biological understanding from previous genetic studies has thus been limited. We performed a multi-ancestry meta-analysis of genome-wide association st...
S-EPMC11396662 | biostudies-literature
UnknownMultinational characterization of neurological phenotypes in patients hospitalized with COVID-19.
Neurological complications worsen outcomes in COVID-19. To define the prevalence of neurological conditions among hospitalized patients with a positive SARS-CoV-2 reverse transcription polymerase chain reaction test in geographically diverse multinational populations during early pandemic, we used e...
S-EPMC8510999 | biostudies-literature
UnknownInternational Analysis of Electronic Health Records of Children and Youth Hospitalized With COVID-19 Infection in 6 Countries.

Importance

Additional sources of pediatric epidemiological and clinical data are needed to efficiently study COVID-19 in children and youth and inform infection prevention and clinical treatment of pediatric patients.

Objective

To describe international hospitalization trends and key ...
S-EPMC8196345 | biostudies-literature
UnknownEvolving phenotypes of non-hospitalized patients that indicate long COVID.

Background

For some SARS-CoV-2 survivors, recovery from the acute phase of the infection has been grueling with lingering effects. Many of the symptoms characterized as the post-acute sequelae of COVID-19 (PASC) could have multiple causes or are similarly seen in non-COVID patients. Accurate...
S-EPMC8474909 | biostudies-literature
UnknownShared genetic architecture of posttraumatic stress disorder with cardiovascular imaging, risk, and diagnoses.
Patients with post-traumatic stress disorder face increased cardiovascular risk. This study examines shared genetic regions between post-traumatic stress disorder and 246 cardiovascular conditions across electronic health records, 82 cardiac imaging, and health behaviors defined by Life's Essential ...
S-EPMC12217169 | biostudies-literature
UnknownHospitalizations Associated With Mental Health Conditions Among Adolescents in the US and France During the COVID-19 Pandemic.

Importance

The COVID-19 pandemic has been associated with an increase in mental health diagnoses among adolescents, though the extent of the increase, particularly for severe cases requiring hospitalization, has not been well characterized. Large-scale federated informatics approaches provid...
S-EPMC9856226 | biostudies-literature
UnknownPolygenic and developmental profiles of autism differ by age at diagnosis.
Although autism has historically been conceptualized as a condition that emerges in early childhood1,2, many autistic people are diagnosed later in life3-5. It is unknown whether earlier- and later-diagnosed autism have different developmental trajectories and genetic profiles....
S-EPMC12571882 | biostudies-literature
UnknownImpact of COVID-19 non-pharmaceutical interventions on bacterial infections in children: an international electronic health record-based study.

Introduction

Non-pharmaceutical interventions (NPIs) such as mask-wearing and social distancing, implemented as public health measures to slow COVID-19 transmission, had a major impact on the epidemiology of viral infections. However, little is known about their influence on bacterial infect...
S-EPMC12699615 | biostudies-literature
UnknownDistinguishing Admissions Specifically for COVID-19 From Incidental SARS-CoV-2 Admissions: National Retrospective Electronic Health Record Study.

Background

Admissions are generally classified as COVID-19 hospitalizations if the patient has a positive SARS-CoV-2 polymerase chain reaction (PCR) test. However, because 35% of SARS-CoV-2 infections are asymptomatic, patients admitted for unrelated indications with an incidentally positive...
S-EPMC9119395 | biostudies-literature
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