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MetabolomicsMolecular structural diversity of mitochondrial cardiolipins
Current strategies used to quantitatively describe the biological diversity of lipids by mass spectrometry are often limited in assessing the exact structural variability of individual molecular species in detail. A major challenge is represented by the extensive isobaric overlap present among lipid...
2021-01-11 | MTBLS636 | MetaboLights
MetabolomicsPhospholipid acyl chain diversity controls the tissue-specific assembly of mitochondrial cardiolipins

Cardiolipin (CL) is a phospholipid specific for mitochondrial membranes and crucial for many core tasks of this organelle. Its side chain configurations are tissue-specific, functionally important and generated via post-biosynthetic remodeling. However, this process lacks the necessary specificit...

2020-05-22 | MTBLS1446 | MetaboLights
ProteomicsA Bacteroides fragilis protease activates host PAR2 to induce intestinal pain and inflammation
Protease-activated receptor 2 (PAR2) is a central regulator of intestinal barrier function, inflammation and pain. Upregulated intestinal proteolysis and PAR2-signaling are implicated in inflammatory bowel diseases (IBDs) and irritable bowel syndrome (IBS), conditions often associated with gut micro...
ORGANISM(S): Bacteroides fragilis (strain ATCC 25285 / NCTC 9343) 
2025-09-28 | PXD059166 | Pride
Chemical proteomics Activity-based protein profiiling Bacteroides fragilis 
ProteomicsProteomes of yeast kinase knock-outs analysed by SWATH-MS
It proves so far difficult to predict the metabolome, even when genome, transcriptome or proteome of a cell are known. In order to globally map enzyme-metabolite relationships, we systematically quantified enzyme expression and metabolite concentrations in Saccharomyces cerevisiae kinase knock-out s...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2018-09-13 | PXD010529 | Pride
Swath Yeast Kinase High-throughput proteomics 
ProteomicsA time-resolved proteomic and prognostic map of COVID-19
We performed quantitative proteomic profiling of 786 plasma samples from COVID-19 inpatients, treated at two different hospitals (Charité – Universitätsmedizin Berlin and University Hospital of Innsbruck). Sampling was performed at multiple time points throughout the course of the disease, to create...
ORGANISM(S): Homo sapiens (Human) 
2021-07-19 | PXD025752 | Pride
Covid-19 Plasma Sars-cov2 Scanningswath 
ProteomicsA proteomic survival predictor for COVID-19 patients in intensive care
Global healthcare systems are challenged by the COVID-19 pandemic. There is a need to optimize allocation of treatment and resources in intensive care, as clinically established risk assessments such as SOFA and APACHE II scores show only limited performance for predicting the survival of severely i...
ORGANISM(S): Homo sapiens (Human) 
2022-03-03 | PXD029009 | Pride
Covid-19 Plasma Sars-cov2 Scanningswath 
UnknownComplement genes contribute sex-biased vulnerability in diverse disorders.
Not available
S-EPMC7319891 | biostudies-literature
UnknownCardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis.
Not available
S-EPMC4648058 | biostudies-literature
UnknownSerum iron levels and the risk of Parkinson disease: a Mendelian randomization study.
Not available
S-EPMC3672214 | biostudies-literature
UnknownA polygenic resilience score moderates the genetic risk for schizophrenia.
Not available
S-EPMC7058518 | biostudies-literature
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