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ProteomicsAn organotypic model of human skin simulates the dermonecrotic effects of Naja nigricollis envenoming
Snakebite envenoming is a neglected tropical disease that kills and maims hundreds of thousands annually. Naja nigricollis, the black-necked spitting cobra, has a cytotoxin-rich venom that is able to cause severe dermonecrosis and is not efficiently neutralized by current antivenoms. Here, we introd...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2023-01-11 | PXD033111 | Pride
Dermonecrosis Snakebite envenoming Naja nigricollis Skin organotypic Proteomics Cytotoxin Keratinocyte 3d cell culture Dda Lc-ms/ms 
ProteomicsQuantitative Single-Cell Proteomics as a Tool to Characterize Cellular Hierarchies
Large-scale single-cell analyses are of fundamental importance in order to capture biological heterogeneity within complex cell systems, but have largely been limited to RNA-based technologies. Here we present a comprehensive benchmarked experimental and computational workflow, which establishes glo...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-10-21 | MSV000090570 | MassIVE
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