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MetabolomicsGut microbiota-induced perturbations in bile acids alter keratinocyte lipid metabolism via FXR-NQO1 signaling in psoriasis
Emerging evidence has shown that microbiota dysbiosis and aberrant bile acids (BAs) profiles are correlated with disease progression. This study elucidates dysregulated BAs metabolism in psoriasis patients and imiquimod-treated female mice, coupled with increased expression of the farnesoid X recept...
2026-03-29 | MTBLS14183 | MetaboLights
MetabolomicsGut microbiota-induced perturbations in bile acids alter keratinocyte lipid metabolism via FXR-NQO1 signaling in psoriasis
Emerging evidence has shown that microbiota dysbiosis and aberrant bile acids (BAs) profiles are correlated with disease progression. This study elucidates dysregulated BAs metabolism in psoriasis patients and imiquimod-treated female mice, coupled with increased expression of the farnesoid X recept...
2026-03-31 | MTBLS14191 | MetaboLights
MetabolomicsThe ULK3 kinase is a key determinant of keratinocyte self-renewal and tumorigenesis targeting the arginine methylome
Epigenetic mechanisms oversee epidermal homeostasis and oncogenesis. The identification of kinases controlling these processes has direct therapeutic implications. We show that ULK3 is a nuclear kinase with elevated expression levels in squamous cell carcinomas (SCCs) arising in multiple body sites,...
2022-11-14 | MTBLS5155 | MetaboLights
ProteomicsKH: Investigation of mouse amniotic fluid for stimulating ability of keratinocyte differentiation depending on the fetal stage
Investigation of mouse amniotic fluid for stimulating ability of keratinocyte differentiation depending on the fetal stage
ORGANISM(S): Mus Musculus (mouse) 
2023-04-13 | PXD024377 | JPOST Repository
TranscriptomicsSphingosine-1-phosphate phosphatase 1 regulates keratinocyte differentiation and epidermal homeostasis
Sphingosine 1-phosphate (S1P) is a bioactive lipid whose levels are tightly regulated by its synthesis and degradation. Intracellularly, S1P is dephosphoryled by the actions of two S1P-specific phosphatases, sphingosine 1-phosphate phosphatase 1 and 2. To identify the physiologic functions of S1P p...
ORGANISM(S): Mus musculus 
2013-08-09 | E-GEOD-40368 | biostudies-arrayexpress
TranscriptomicsLysate affects on keratinocyte scratch assays
The aim of this study was to provide proof of principle as to whether probiotic bacteria or their extracts, could stimulate cutaneous wound healing. To this end, we have used a keratinocyte monolayer scratch assay which assesses one important aspect of wound healing, re-epithelialization. Primary hu...
ORGANISM(S): Homo sapiens 
2016-03-23 | E-MTAB-3485 | biostudies-arrayexpress
ProteomicsIdentification the proteins interacted with SNHG26 in human keratinocytes
The cell transition from an inflammatory phase to a subsequent proliferative phase is crucial for wound healing, yet the driving mechanism remains unclear. By profiling lncRNA expression changes during human skin wound healing and screening lncRNA functions, we identified SNHG26 as a pivotal regulat...
ORGANISM(S): Homo sapiens (Human) 
2024-08-28 | PXD055231 | Pride
Snhg26 Keratinocyte 
TranscriptomicsZNF750 in late keratinocyte differentiation
Disrupted skin barrier due to altered keratinocyte differentiation is common in pathologic conditions such as atopic dermatitis, ichthyosis and psoriasis. However, the molecular cascades governing keratinocyte terminal differentiation are still poorly understood. We have previously demostrated that ...
ORGANISM(S): Homo sapiens 
2012-09-24 | E-GEOD-38039 | biostudies-arrayexpress
ProteomicsEffect of integrin α3β1 and/or integrin α9β1 expression on the mouse keratinocyte secretome
A parental immortalized mouse keratinocyte cell line which lacks integrin α3β1 and α9β1 were engineered to express either α3β1, α9β1, or α3β1 and α9β1 in combination. The conditioned medium from these cell lines were analyzed by MS/MS.
ORGANISM(S): Mus musculus (Mouse) 
2022-02-15 | PXD018425 | Pride
Keratinocytes Integrin α3β1 Integrin α9β1 Secretome 
TranscriptomicsTranscription profiling of human and mouse keratinocytes infected with AD and Ad-NotchIC viruses reveals cross-regulation between Notch and p63 in keratinocyte commitment to differentiation
Notch signaling promotes commitment of keratinocytes to differentiation and suppresses tumorigenesis. p63, a p53 family member, has been implicated in establishment of the keratinocyte cell fate and/or maintenance of epithelial self-renewal. Here we show that p63 expression is suppressed by Notch1 a...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5229 | biostudies-arrayexpress
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