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GenomicsGenome-wide chromatin maps of T-cell acute lymphoblastic leukemia (T-ALL) [ChIP-seq]
Here we modeled T-ALL resistance to Notch inhibition, identifying M-bM-^@M-^XpersisterM-bM-^@M-^Y cells that readily expand in the presence of gamma secretase inhibitor (GSI) and the absence of Notch signaling. Rare persister cells are already present in naM-CM-/ve T-ALL populations, and the reversi...
ORGANISM(S): Homo sapiens 
2014-03-01 | E-GEOD-54379 | biostudies-arrayexpress
UnknownHematopoietic RIPK1 deficiency results in bone marrow failure caused by apoptosis and RIPK3-mediated necroptosis.
Not available
S-EPMC4209989 | biostudies-literature
UnknownNOD2, RIP2 and IRF5 play a critical role in the type I interferon response to Mycobacterium tuberculosis.
Not available
S-EPMC2698121 | biostudies-literature
UnknownImprinted and ancient gene: a potential mediator of cancer cell survival during tryptophan deprivation.
Not available
S-EPMC6251197 | biostudies-literature
UnknownCutting edge: RIPK1 Kinase inactive mice are viable and protected from TNF-induced necroptosis in vivo.
Not available
S-EPMC4119562 | biostudies-literature
TranscriptomicsExpression data from vehicle or PD-0332991 treated human T-ALL lines
Cyclin D3 is critical hematopoiesis and loss of cyclin D3 leads to resistance to transformation of bone marrow progenitors by Notch1-IC. We used a small molecule targeting cyclin D3:CDK4/6 activity to study whether its inhibition is an effective therapeutic strategy. We analyzed T-ALL lines in vitro...
ORGANISM(S): Homo sapiens 
2012-12-13 | E-GEOD-40635 | biostudies-arrayexpress
UnknownDendritic Cell RIPK1 Maintains Immune Homeostasis by Preventing Inflammation and Autoimmunity.
Not available
S-EPMC5760320 | biostudies-literature
UnknownTYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia.
Not available
S-EPMC3651770 | biostudies-literature
GenomicsCore transcriptional regulatory circuit controlled by the tal1 complex in human t-cell acute lymphoblastic leukemia (Subseries)
The oncogenic transcription factor TAL1/SCL is aberrantly overexpressed in over 40% of cases of T-cell acute lymphoblastic leukemia (T-ALL), emphasizing the importance of the TAL1-regulated transcriptional program in the molecular pathogenesis of T-ALL. Here we identify the core transcriptional regu...
ORGANISM(S): Homo sapiens 
2012-03-14 | E-GEOD-33850 | biostudies-arrayexpress
UnknownPPT1 is a negative regulator of STING signaling in cancer cells and its inhibition reactivates immune surveillance in cold tumors.
Not available
S-EPMC12501185 | biostudies-literature
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