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UnknownDiabetic Kidney Disease Alters the Transcriptome and Function of Human Adipose-Derived Mesenchymal Stromal Cells but Maintains Immunomodulatory and Paracrine Activities Important for Renal Repair.
Mesenchymal stem/stromal cells (MSCs) facilitate repair in experimental diabetic kidney disease (DKD). However, the hyperglycemic and uremic milieu may diminish regenerative capacity of patient-derived therapy. We hypothesized that DKD reduces human MSC paracrine function. Adipose-derived MSC from 3...
S-EPMC8336004 | biostudies-literature
UnknownIntra- and Intermolecular Charge-Transfer Dynamics of Carbene-Metal-Amide Photosensitizers.
A series of steady-state and time-resolved spectroscopies were performed on a set of eight carbene-metal-amide (cMa) complexes, where M = Cu and Au, that have been used as photosensitizers for photosensitized electrocatalytic reactions. Using ps-to-ns and ns-to-ms transient absorption spectroscopies...
S-EPMC11056983 | biostudies-literature
UnknownSingle cell atlas of human gastric muscle immune cells and macrophage-driven changes in idiopathic gastroparesis.
Gastrointestinal immune cells, particularly muscularis macrophages (MM) interact with the enteric nervous system and influence gastrointestinal motility. Here we determine the human gastric muscle immunome and its changes in patients with idiopathic gastroparesis (IG). Single cell sequencing was per...
S-EPMC10879712 | biostudies-literature
UnknownElliptic anisotropy measurement of the f<sub>0</sub>(980) hadron in proton-lead collisions and evidence for its quark-antiquark composition.
Despite the f0(980) hadron having been discovered half a century ago, the question about its quark content has not been settled: it might be an ordinary quark-antiquark ( qq¯ ) meson, a tetraquark ( qq¯qq¯ ) exotic state, a kaon-antikaon ( KK¯ ) molecule, or a quark-antiquark-gluon ( qq¯g...
S-EPMC12391314 | biostudies-literature
UnknownTranscriptomic signatures reveal immune dysregulation in human diabetic and idiopathic gastroparesis.

Background

Cellular changes described in human gastroparesis have revealed a role for immune dysregulation, however, a mechanistic understanding of human gastroparesis and the signaling pathways involved are still unclear.

Methods

Diabetic gastroparetics, diabetic non-gastroparetic co...
S-EPMC6081936 | biostudies-literature
UnknownA Randomized Trial of Topical Fibrinogen-Depleted Human Platelet Lysate Treatment of Dry Eye Secondary to Chronic Graft-versus-Host Disease.

Purpose

The purpose of the study was to evaluate, as a pilot trial, safety and tolerability of CAM-101 10% and 30% topical ophthalmic fibrinogen-depleted human platelet lysate (FD hPL) solution in patients with dry eye disease (DED) secondary to graft-versus-host disease (GvHD) after 6 weeks...
S-EPMC9562362 | biostudies-literature
UnknownMultiparametric Magnetic Resonance Elastography Improves the Detection of NASH Regression Following Bariatric Surgery.
Disease monitoring in nonalcoholic steatohepatitis (NASH) is limited by absence of noninvasive biomarkers of disease regression or progression. We aimed to examine the role of multiparametric three-dimensional magnetic resonance elastography (3D-MRE) and magnetic resonance imaging proton density fat...
S-EPMC6996337 | biostudies-literature
UnknownThe Role of Three-Dimensional Magnetic Resonance Elastography in the Diagnosis of Nonalcoholic Steatohepatitis in Obese Patients Undergoing Bariatric Surgery.
The lack of reliable, noninvasive methods to diagnose early nonalcoholic steatohepatitis (NASH) is a major unmet need. We aimed to determine the diagnostic accuracy of three-dimensional magnetic resonance elastography (3D-MRE), with shear stiffness measured at 60 Hz, damping ratio at 40 Hz, and magn...
S-EPMC6591099 | biostudies-literature
UnknownSenolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease.

Background

Senescent cells, which can release factors that cause inflammation and dysfunction, the senescence-associated secretory phenotype (SASP), accumulate with ageing and at etiological sites in multiple chronic diseases. Senolytics, including the combination of Dasatinib and Quercetin ...
S-EPMC6796530 | biostudies-literature
UnknownHypoxia-Inducible Factor 1α Stabilization Restores Epigenetic Control of Nitric Oxide Synthase 1 Expression and Reverses Gastroparesis in Female Diabetic Mice.

Background & aims

Although depletion of neuronal nitric oxide synthase (NOS1)-expressing neurons contributes to gastroparesis, stimulating nitrergic signaling is not an effective therapy. We investigated whether hypoxia-inducible factor 1α (HIF1A), which is activated by high O2 co...
S-EPMC10840755 | biostudies-literature
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