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TranscriptomicsRole of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation (RNA-seq)
Cancer cells frequently depend on chromatin regulatory activities to maintain a malignant phenotype. Here, we show that leukemia cells require the mammalian SWI/SNF chromatin remodeling complex for their survival and aberrant self-renewal potential. While Brg1, an ATPase subunit of SWI/SNF, is known...
ORGANISM(S): Mus musculus 
2013-12-02 | E-GEOD-52623 | biostudies-arrayexpress
GenomicsThe effect of bound RSC/nucleosome complex on chromatin architecture and gene expression at the GAL genes of yeast
How is chromatin architecture established and what role does it play in activation of transcription? We show that a regulatory locus in yeast (the UASg) bears, in addition to binding sites for the activator Gal4, sites bound by the protein RSC. RSC tightly positions a nucleosome, evidently partial...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-01 | E-GEOD-20078 | biostudies-arrayexpress
GenomicsThe maize methylome modulates mRNA splicing and reveals widespread paramutation guided by small RNA.
Methylation of chromosomal DNA in animals and plants is a fundamental mechanism of epigenetic regulation, and the maize genome, with its diverse complement of transposons and repeats, is a paradigm for transgenerational mechanisms such as paramutation and imprinting. We have determined the genome-wi...
ORGANISM(S): Zea mays 
2013-06-03 | E-GEOD-39232 | biostudies-arrayexpress
GenomicsHigh definition profiling of mammalian DNA methylation by array capture and single molecule bisulfite sequencing
DNA methylation stabilizes developmentally programmed gene expression states. Aberrant methylation is associated with disease progression and is a common feature of cancer genomes. Presently, few methods enable quantitative, large-scale, single-base resolution mapping of DNA methylation states in d...
ORGANISM(S): Homo sapiens 
2009-07-08 | E-GEOD-17001 | biostudies-arrayexpress
UnknownNR4A1 and NR4A2 orphan nuclear receptors regulate endothelial-to-hematopoietic transition in mouse hematopoietic stem cell specification.
Not available
S-EPMC11634030 | biostudies-literature
UnknownPathologist-Read vs AI-Driven Assessment of Tumor-Infiltrating Lymphocytes in Melanoma.
Not available
S-EPMC12232186 | biostudies-literature
UnknownTIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics.
Not available
S-EPMC5576574 | biostudies-literature
UnknownAzithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC7884931 | biostudies-literature
UnknownEffect of Hydroxychloroquine in Hospitalized Patients with Covid-19.
Not available
S-EPMC7556338 | biostudies-literature
UnknownTocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC8084355 | biostudies-literature
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