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TranscriptomicsMicroarray analysis of Gene expression in limb muscles of three mouse models of Kennedy disease/SBMA
Emerging evidence implicates transcriptional dyseregulation within skeletal muscle in the pathogenesis of Kennedy disease/spinal bulbar muscular atrophy (KD/SBMA). We therefore broadly characterized gene expression in skeletal muscle of three independently generated mouse models of this disorder. Th...
ORGANISM(S): Mus musculus 
2010-10-12 | E-GEOD-10190 | biostudies-arrayexpress
GenomicsAmplification of siRNA in Caenorhabditis elegans generates a transgenerational sequence-targeted histone H3 lysine 9 methylation footprint
Exogenous double-stranded RNA (dsRNA) has been shown to exert homology-dependent effects at the level of both target mRNA stability and chromatin structure. Using C. elegans undergoing RNAi as an animal model, we have investigated the generality, scope, and longevity of chromatin-targeted dsRNA effe...
ORGANISM(S): Caenorhabditis elegans 
2012-01-06 | E-GEOD-32631 | biostudies-arrayexpress
UnknownMapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers.
Not available
S-EPMC5693923 | biostudies-literature
UnknownChanges of pituitary gland volume in Kennedy disease.
Not available
S-EPMC7965206 | biostudies-literature
TranscriptomicsA nuclear Argonaute promotes germline immortality and epigenetic inheritance across generations
dsRNA-mediated gene silencing (RNAi) can be inherited for multiple generations in C. elegans. To understand this process we conducted a genetic screen for animals defective for transmitting RNAi silencing signals to future generations. This screen identified the gene heritable RNAi defective (hrde)-...
ORGANISM(S): Caenorhabditis elegans 
2012-07-30 | E-GEOD-38041 | biostudies-arrayexpress
TranscriptomicsDistinct phases of siRNA synthesis in an endogenous RNAi pathway in C. elegans soma
Endogenous RNA-directed RNA polymerases (RdRPs) are cellular components capable of synthesizing new complementary RNAs from existing RNA templates. We present evidence for successive engagement of two different RdRPs in an endogenous siRNA-based mechanism targeting specific mRNAs in C. elegans soma....
ORGANISM(S): Caenorhabditis elegans 
2010-02-01 | E-GEOD-19414 | biostudies-arrayexpress
UnknownChromatin Compaction by Small RNAs and the Nuclear RNAi Machinery in C. elegans.
Not available
S-EPMC6588724 | biostudies-literature
TranscriptomicsComparison of small RNA levels in Dicer helicase mutants
Years after the discovery that Dicer is a key enzyme in gene-silencing, the role of its helicase domain remains enigmatic. Here we show that this domain is critical for accumulation of certain endogenous small interfering RNAs (endo-siRNAs) in C. elegans. The domain is required for the production of...
ORGANISM(S): Caenorhabditis elegans 
2010-04-01 | E-GEOD-20336 | biostudies-arrayexpress
UnknownC-type lectin receptor CLEC4A2 promotes tissue adaptation of macrophages and protects against atherosclerosis.
Not available
S-EPMC8752790 | biostudies-literature
UnknownTenascin-C: Form versus function.
Not available
S-EPMC4422809 | biostudies-literature
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