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ProteomicsStable nuclear expression of ATP8 and ATP6 genes rescues a mtDNA Complex V null mutant
We explore the possibility of re-engineering mitochondrial genes and expressing them from the nucleus as an approach to rescue defects arising from mitochondrial DNA mutations. We have used a patient cybrid cell line with a single point mutation in the overlap region of the ATP8 and ATP6 genes of th...
ORGANISM(S): Homo Sapiens (human) 
2016-08-12 | MSV000080037 | MassIVE
TranscriptomicsDifferential neuronal targeting of a new and 2 known calcium channel M-NM-24 subunit splice variants correlates with their regulation of gene expression
The M-NM-2 subunits of voltage-gated calcium channels regulate surface expression and gating of CaV1 and CaV2 M-NM-11 subunits, and thus contribute to neuronal excitability, neurotransmitter release and calcium-induced gene regulation. In addition certain M-NM-2 subunits are targeted into the nucleu...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-50822 | biostudies-arrayexpress
TranscriptomicsForkhead transcription factors establish origin timing and long-range clustering in S. cerevisiae [Sequence Data]
The replication of eukaryotic chromosomes is organized temporally and spatially within the nucleus through epigenetic regulation of replication origin function. The characteristic initiation timing of specific origins is thought to reflect their chromatin environment or sub-nuclear positioning, how...
ORGANISM(S): Saccharomyces cerevisiae 
2012-01-20 | E-GEOD-33677 | biostudies-arrayexpress
MetabolomicsGlobal untargeted serum metabolomic analyses nominate metabolic pathways responsive to loss of expression of the orphan metallo beta-lactamase, MBLAC1
The C. elegans gene swip-10 encodes an orphan metallo beta-lactamase that genetic studies indicate is vital for limiting neuronal excitability and viability. Sequence analysis indicates that the mammalian gene Mblac1 is the likely ortholog of swip-10, with greatest sequence identity localized...
2019-03-12 | MTBLS650 | MetaboLights
TranscriptomicsTHOC5, a member of the mRNA export complex, is essential for hematopoiesis in vivo and is required for CSF-1 induced macrophage differentiation
THOC5, a member of the mRNA export complex, is essential for hematopoiesis in vivo and is required for CSF-1 induced macrophage differentiation, thereby playing a key role in the mRNA export of immediate early genes induced by CSF-1 stimulation. Hematopoiesis, growth, differentiation, and commitment...
ORGANISM(S): Mus musculus 
2013-12-24 | E-GEOD-41170 | biostudies-arrayexpress
TranscriptomicsHeLa cell mitochondrial microRNAs
MicroRNAs (miRNAs) are small non-coding RNAs that associate with Argonaute 2 protein to regulate gene expression at the post-transcriptional level in the cytoplasm. However, recent studies have reported that some miRNAs localize to and function in other cellular compartments. Mitochondria harbour th...
ORGANISM(S): Homo sapiens 
2011-10-05 | E-GEOD-24761 | biostudies-arrayexpress
GenomicsKLF4 Dependent Phenotypic Modulation of SMCs Plays a Key Role in Regulating Plaque Pathogenesis
Cardiovascular disease is the leading cause of death in developed countries and there is compelling evidence that the majority of these fatalities are secondary to rupture of unstable atherosclerotic plaques. However, the mechanisms that control plaque stability are poorly understood, although it is...
ORGANISM(S): Mus musculus 
2015-04-24 | E-GEOD-65812 | biostudies-arrayexpress
TranscriptomicsNucleosome maps of the human cytomegalovirus genome reveal a temporal switch in chromatin organization linked to a major IE protein
Human CMV (hCMV) establishes lifelong infections in most of us, causing developmental defects in human embryos and life-threatening disease in immunocompromised individuals. During productive infection, the viral >230,000-bp dsDNA genome is expressed widely and in a temporal cascade. The hCMV genome...
ORGANISM(S): Human Herpesvirus 5 
2013-07-17 | E-GEOD-48875 | biostudies-arrayexpress
GenomicsGene expression profiling and TF occupancy upon treatment with the FXR agonist obeticholic acid
The farnesoid X receptor (FXR) is a nuclear receptor activated by bile acids and regulates bile acid metabolism, glucose and cholesterol homeostasis. From mouse studies we know that the novel FXR agonist obeticholic acid (OCA) regulates expression of many genes in the liver, but there is currently n...
ORGANISM(S): Mus musculus 
2016-01-27 | E-GEOD-73624 | biostudies-arrayexpress
TranscriptomicsHistone acetylation H3K9ac ChIP-seq of Arabidopsis thaliana leaves for three genotypes (Col-0 wild type, gsnor1-3, axe1-5/hda6) in low light and dark conditions
Plants were grown for 4 weeks under short day (10 h light/14 h dark and 20 °C/16 °C, respectively). The relative humidity during the day and night was 50 %. Then, plants were transferred at 11 am (5 h after turning on the light) for 4 h either to dark (0 µE, 22 °C) or low light (100-130 µE, 22 °C) c...
ORGANISM(S): Arabidopsis thaliana 
2021-05-28 | E-MTAB-9299 | biostudies-arrayexpress
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