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TranscriptomicsMultilineage dysplasia does not influence prognosis in patients with CEBPA mutated AML supporting the WHO proposal to classify these patients as a unique entity
By WHO 2008, CEBPA-mutated AML became a provisional subentity, but it remains to be clarified how CEBPAmut AML with multilineage dysplasia (MLD; ?50% dysplastic cells in 2-3 lineages) but no other MDS-related feature should be classified. We investigated 108 CEBPAmut AML (15.7-87.6 years) for the im...
ORGANISM(S): Homo sapiens 
2012-06-14 | E-GEOD-33223 | biostudies-arrayexpress
TranscriptomicsAcute myeloid leukemia with CEBPA double-mutations harbors in 76.8% of cases concomitant molecular mutations with TET2 and GATA2 alterations demonstrating strong prognostic impact
Acute myeloid leukemia (AML) with CEBPA mutations is determined as provisional entity in the current WHO. A difference in clinical outcome between single- (sm) and double-mutated (dm) cases has been reported, whereupon dm cases were shown to be associated with longer overall survival (OS). The occur...
ORGANISM(S): Homo sapiens 
2013-04-20 | E-GEOD-42064 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of centromeric proteins CenpA, CenpC and CenpH from human cell lines which contain either a neocentromere in band 13q21 or no neocentric chromosome
Chromatin Immunoprecipitation of Centromeric Proteins, CenpA, CenpC or CenpH from cell lines which contain either a neocentromere in band 13q21 or no neocentric chromosomes

Processed data files with additional statistics are available for download from
ORGANISM(S): Homo sapiens 
2008-03-22 | E-TABM-257 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of centromeric proteins CenpA, CenpC and CenpH from human cell line BBB, which contains a neocentromere in band 13q33.1
Chromatin Immunoprecipitation of Centromeric Proteins, CenpA, CenpC or CenpH from cell line BBB, which contains a neocentromere in band 13q33.1

Processed data files with additional statistics are available for download from
ORGANISM(S): Homo sapiens 
2008-03-22 | E-TABM-245 | biostudies-arrayexpress
TranscriptomicsFunctional characterization of C. elegans Y-box binding proteins reveals tissue-specific functions and a critical role in the formation of polysomes (RIP-Seq)
We present a basic characterization of the function of Y-box binding proteins (YBPs) in C. elegans. YBPs in other organisms are known RNA-binding proteins. Our global analysis of associated mRNAs supports a role of YBPs as general mRNA binders in C.elegans. FLAG IPs were performed on transgenic anim...
ORGANISM(S): Caenorhabditis elegans 
2015-01-08 | E-GEOD-62856 | biostudies-arrayexpress
TranscriptomicsFunctional characterization of C. elegans Y-box binding proteins reveals tissue-specific functions and a critical role in the formation of polysomes (ribosome)
We present a basic characterization of the function of Y-box binding proteins in C. elegans. Besides playing an important role for fertility in the germline (all four CEY proteins), we found that the presence of CEY-1 and CEY-4 is essential for the assembly of larger polysomes in the soma. We theref...
ORGANISM(S): Caenorhabditis elegans 
2015-01-08 | E-GEOD-62859 | biostudies-arrayexpress
Genomicsproj022_chipseq
The mechanisms that recruit the major Polycomb-group (PcG) complexes PRC1 and PRC2 to target sites in vertebrate cells are not well understood. Building on recent studies that have determined a reciprocal relationship between DNA methylation and Polycomb activity, we demonstrate that in methylation ...
ORGANISM(S): Mus musculus 
2014-05-23 | E-MTAB-2481 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human umbilical vein endothelial cells (HUVEC) treated with thrombin and leukotriene D4 (LTD4) with ethanol controls to delinate Cysteinyl leukotrienes mode of action
Cysteinyl leukotrienes (cysLT), i.e. LTC4, LTD4, and LTE4, are lipid mediators derived from the 5-lipoxygenase pathway. The cysLT receptors cysLT1-R and cysLT2-R are expressed on different target cells and mediate inflammatory reactions in tissue- and LT-R-specific ways. Though endothelial cells (EC...
ORGANISM(S): Homo sapiens 
2007-10-27 | E-GEOD-3589 | biostudies-arrayexpress
TranscriptomicsFunctional characterization of C. elegans Y-box binding proteins reveals tissue-specific functions and a critical role in the formation of polysomes (RNA-Seq)
We present a basic characterization of the function of Y-box binding proteins in C. elegans. Besides playing an important role for fertility in the germline (all four CEY proteins), we found that the presence of CEY-1 and CEY-4 is essential for the assembly of larger polysomes in the soma. We theref...
ORGANISM(S): Caenorhabditis elegans 
2015-01-08 | E-GEOD-62858 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of centromeric proteins CenpC and CenpH from human cell lines containing a neocentromere in band 13q32
Chromatin Immunoprecipitation of Centromeric Proteins, CenpA, CenpC or CenpH from human cell lines containing a neocentromere in band 13q32

Processed data files with additional statistics are available for download from
ORGANISM(S): Homo sapiens 
2008-03-22 | E-TABM-238 | biostudies-arrayexpress
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