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TranscriptomicsSingle-nucleus mRNA-sequencing reveals dynamics of lipogenic and thermogenic adipocyte populations in murine brown adipose tissue in response to cold exposure
Brown adipocyte-specific ChREBP knockout were generated by crossing mice with a floxed exon1a in the Mlxipl gene with Ucp1-Cre mice. These ChREBPflox/flox Ucp1-Cre+ (Cre+) mice and ChREBP-expressing control (Cre-) mice were studied under various conditions of BAT activation. Housing at room temperat...
ORGANISM(S): Mus musculus 
2025-11-10 | E-MTAB-15819 | biostudies-arrayexpress
TranscriptomicsThe nuclear actin-related protein Arp6 contributes to the radial positioning of chromosome territories.
The chromatin of individual chromosomes is organized into chromosome territories (CTs) in the interphase nucleus. The spatial arrangement of CTs is non-random and evolutionarily conserved. The gene-dense and gene-poor CTs are positioned in the nuclear center and periphery, respectively. As candidate...
ORGANISM(S): Gallus gallus 
2015-11-04 | E-GEOD-14220 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of human lymphoblastic cell line GM06990 using anti Histone H3K4me1, H3K4me2, H3K4me3, H3ac and H4ac antibodies using an ENCODE array
ENCODE ChIP/chip study using lymphoblastic cell line GM06990 and anti Histone H3K4me1, H3K4me2, H3K4me3, H3ac and H4ac antibodies.
ORGANISM(S): Homo sapiens 
2005-06-13 | E-MEXP-269 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of human and chimp cell lines GM06990, HFL1, HeLaS3, MOLT4 and PTR8 with anti Histone H3K4me1, H3K4me2, H3K4me3, H3ac and H4ac antibodies using an ENCODE array
ENCODE ChIP/chip study using human lymphoblastoid cell line GM06990; human cervix carcinoma cell line HeLaS3; human fetal lung fibroblast cell line HFL1; human T cell line MOLT4; chimpanzee lymphoblastoid cell line PTR8; and anti Histone H3K4me1 (Abcam; ab8895); H3K4me2 (Abcam; ab7766); H3K4me3 (Abc...
ORGANISM(S): Pan troglodytes 
2006-08-30 | E-TABM-138 | biostudies-arrayexpress
TranscriptomicsTumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase
Deregulated expression of MYC is a driver of colorectal carcinogenesis, necessitating novel strategies to inhibit MYC function. The ubiquitin ligase HUWE1 (HECTH9, ARFBP1, MULE) associates with both MYC and the MYC-associated protein MIZ1. We show here that HUWE1 is required for growth of colorecta...
ORGANISM(S): Homo sapiens 
2014-10-21 | E-GEOD-59223 | biostudies-arrayexpress
GenomicsChIP-seq-based analysis of differential K27me3 coverage in neuroblastoma cell lines treated with epigenetic drugs
The impact of drugs inhibiting DNA methylation (5-aza-2'-deoxycytodine, DAC) and EZH2 (EPZ-6438) on H3K27me3 coverage was analyzed in two neuroblastoma cell lines. Parallel analyses investigated associated changes in RNA expression and DNA methylation. The neuroblastoma cell lines Be(2)-C and IMR5-7...
ORGANISM(S): Homo sapiens 
2016-09-08 | E-GEOD-80445 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of different strains of yeast exposed to arsenic stress
Effect of arsenic stress on cellular metabolism, respectively on transcription factors in the yeast Saccharomyces cerevisiae
ORGANISM(S): Saccharomyces cerevisiae 
2008-09-02 | E-MEXP-1075 | biostudies-arrayexpress
TranscriptomicsExpression profiles of globular bushy cells (GBCs) during maturation
Calyx of Held giant presynaptic terminals in the medial nucleus of the trapezoid body of the auditory brainstem form axosomatic synapses that have advanced to one of the best-studied synaptic system of the mammalian brain. As the auditory system matures and adjusts to high fidelity synaptic transmis...
ORGANISM(S): Rattus norvegicus 
2014-06-24 | E-GEOD-49599 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of response to chronic constant hypoxia in adult Zebrafish hearts
Gene expression profile of the response to chronic constant hypoxia in the heart of adult zebrafish Experiment Overall Design: 10 arrays (5 for hypoxia and 5 normoxia); in total 8 biological samples plus 2 technical replicates
ORGANISM(S): Danio rerio 
2007-10-25 | E-GEOD-4989 | biostudies-arrayexpress
GenomicsSalt augments macrophage-driven host defense in the skin
Immune cells regulate a hypertonic microenvironment in the skin; however, possible functions of increased skin Na+ concentrations are unknown. We found that Na+ accumulated at the site of bacterial skin infections in humans and in mice. We used the protozoan parasite Leishmania (L.) major as a model...
ORGANISM(S): Mus musculus 
2015-02-26 | E-MTAB-3343 | biostudies-arrayexpress
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