The nuclear actin-related protein Arp6 contributes to the radial positioning of chromosome territories.

ABSTRACT: The chromatin of individual chromosomes is organized into chromosome territories (CTs) in the interphase nucleus. The spatial arrangement of CTs is non-random and evolutionarily conserved. The gene-dense and gene-poor CTs are positioned in the nuclear center and periphery, respectively. As candidates for key molecules involved in nuclear organization, we have investigated the nuclear actin-related proteins (Arps), which include the evolutionarily conserved actin-family together with conventional actin. We used a conditional knockout system with chicken DT40 cells to analyze the functions of the actin-related protein Arp6. Consistent with a previous identification of Arp6 in the SRCAP chromatin remodeling complex, the histone variant H2AZ was significantly decreased in the chromatin of Arp6

ORGANISM(S): Gallus gallus

SUBMITTER: Yukako Oma 

PROVIDER: E-GEOD-14220 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress