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GenomicsDistinct activities of Myf5 and MyoD indicate sequential roles in skeletal muscle lineage specification and differentiation (ChIP-Seq)
In this work we compare the molecular functions of Myf5 and MyoD, two highly related bHLH transcription factors that regulate skeletal muscle specification and differentiation. We find MyoD and Myf5 bind the same sites genome-wide but have distinct functions: Myf5 induces histone acetylation without...
ORGANISM(S): Mus musculus 
2016-03-01 | E-GEOD-75370 | biostudies-arrayexpress
GenomicsDistinct activities of Myf5 and MyoD indicate sequential roles in skeletal muscle lineage specification and differentiation
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2016-03-01 | E-GEOD-75632 | biostudies-arrayexpress
GenomicsEstablishment of regions of genomic activity during the Drosophila maternal-to-zygotic transition
A conspicuous feature of early animal development is the lack of transcription from the embryonic genome, and it typically takes several hours to several days (depending on the species) until widespread transcription of the embryonic genome begins. Although this transition is ubiquitous, relatively ...
ORGANISM(S): Drosophila melanogaster 
2014-10-16 | E-GEOD-58935 | biostudies-arrayexpress
TranscriptomicsChIP-chip mapping of RNA polymerase II binding in D.melanogaster stage 5 embryos
ChIP-chip was performed using chromatin isolated from formaldehyde crosslinked, stage 5 embryos, and 8WG16 monoclonal antibody against RNA polymerase II(Covance Inc.). The chromatin immunoprecitation and hybridization for each antibody were carried out in duplicates, and in each chromatin immunopr...
ORGANISM(S): Drosophila melanogaster 
2011-02-28 | E-TABM-1130 | biostudies-arrayexpress
TranscriptomicsCooperative binding of DNA sequence non-specific HMGbox Factor Ubf and TBP-TAF complex SL1 determines RNA Polymerase I promoter recognition in vivo and its dysfunction underlies the Ubf-E210K neuroregression syndrome
Transcription of the >200 rRNA genes (rDNA) by RNA Polymerase I (RPI) determines as much as 35% of total nuclear RNA synthesis and is a major determinant of cell growth implicated in a range of hypertrophic and developmental disorders. Activation of the rDNA involves the formation of an extended nuc...
ORGANISM(S): Mus musculus 
2021-08-31 | E-MTAB-10433 | biostudies-arrayexpress
TranscriptomicsChromatin interactions involving super-enhancers associate with specific expression patterns of target genes
Super-enhancers may regulate target genes through chromatin looping. We connected super-enhancers in the K562 chronic myelogenous leukemia cell line with chromatin interactions identified from Chromatin Interaction Analysis with Paired-End Tag (ChIA-PET) data. Gene expression at proximal elements th...
ORGANISM(S): Homo sapiens 
2017-05-01 | E-GEOD-77125 | biostudies-arrayexpress
TranscriptomicsChromatin accessibility in the adult male and female naked mole rat hypothalamus before and during colony removal
The naked mole-rat (NMR; Heterocephalus glaber) is a eusocial subterranean rodent with a highly unusual set of physiological traits, such as extreme longevity, that has attracted great interest amongst the scientific community. However, the genetic basis of most of these traits has not been elucidat...
ORGANISM(S): Heterocephalus glaber 
2025-11-22 | E-MTAB-14649 | biostudies-arrayexpress
TranscriptomicsLow Input Micro-C (Pico-C) data of Drosophila melanogaster embryos across early nuclear cycles
Low-input Micro-C (Pico-C) was performed on hand-sorted PCNA-eGFP embryos at interphase from nuclear cycles (NCs) 9 to 14, including double knockdowns of Zelda and GAF and their respective controls (NC14), as well as embryos injected with α-amanitin or water (NC14). ATAC-seq was performed on double ...
ORGANISM(S): Drosophila melanogaster 
2025-11-10 | E-MTAB-14477 | biostudies-arrayexpress
GenomicsBIM is the primary mediator of MYC-induced apoptosis in multiple solid tissues
C-MYC (henceforth MYC) is one of the most frequently overexpressed oncogenes in human cancer and even modestly deregulated MYC expression can initiate ectopic proliferation in many post-mitotic, terminally differentiated cell types in vivo. Metazoan organisms have consequently evolved a number of me...
ORGANISM(S): Homo sapiens 
2015-05-18 | E-GEOD-59001 | biostudies-arrayexpress
GenomicsA validated gene regulatory network and GWAS identifies early regulators of T-cell associated diseases (ChIP-Seq)
For the purpose of the Gene Regulatory Network validation we have performed chromatin-immunoprecipitation sequencing (ChIP-Seq) experiment for three transcription factors; namely GATA3, MAF and MYB. ChIP-Seq of GATA3, MAF and MYB in human naïve CD4+ T-cells differentiated toward Th1 and Th2 until d...
ORGANISM(S): Homo sapiens 
2015-11-12 | E-GEOD-72266 | biostudies-arrayexpress
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