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TranscriptomicsDonor lung tissues: Control vs. Primary graft dysfunction (PGD)
Primary graft dysfunction (PGD) continues to be a major cause of early death after lung transplantation. Moreover, there remains a lack of accurate pre-transplant molecular markers for predicting PGD. To identify distinctive gene expression signatures associated with PGD, we profiled human donor lun...
ORGANISM(S): Homo sapiens 
2008-09-15 | E-GEOD-9102 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of lung tissue from cardiac death and brain death donors, both pre and post transplant
Lung donation after cardiac death (DCD), in contrast to donation after brain death (DBD), is a promising and increasingly common method to help relieve the shortage of donor organs. However, the pathogenetic consequences of retrieved lungs after DCD vs. DBD have not been clarified. We aimed to study...
ORGANISM(S): Homo sapiens 
2009-11-11 | E-GEOD-18995 | biostudies-arrayexpress
TranscriptomicsClaudin 1 mediates TNF alpha-induced gene expression and cell migration in human lung carcinoma cells
Epithelial-mesenchymal transition (EMT) is an important mechanism in carcinogenesis. To determine the mechanisms that are involved in the regulation of EMT is crucial to develop new biomarkers and therapeutic targets towards cancers. In this study, when TGFß1 and TNFa were used to induce EMT in hum...
ORGANISM(S): Homo sapiens 
2012-06-12 | E-GEOD-32254 | biostudies-arrayexpress
TranscriptomicsMetabolomic heterogeneity of severe pulmonary arterial hypertension
Although multiple gene and protein expression have been extensively profiled in human pulmonary arterial hypertension (PAH), the mechanism for the development and progression of pulmonary hypertension remains elusive. Analysis of the global metabolomic heterogeneity within the pulmonary vascular sy...
ORGANISM(S): Homo sapiens 
2014-11-14 | E-GEOD-53408 | biostudies-arrayexpress
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