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TranscriptomicsExpression analysis of Escherichia coli MG1655 K-12 WT and M-bM-^HM-^Ffnr mutant
Investigation of whole genome gene expression level changes in a Escherichia coli MG1655 K-12 ?fnr mutant, compared to the wild-type strain. The mutations engineered into this strain produce a strain lacking the FNR protein. WT strains were grown under aerobic and anaerobic growth conditions. A six ...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2013-06-20 | E-GEOD-41189 | biostudies-arrayexpress
TranscriptomicsExpression analysis of Escherichia coli MG1655 K-12 M-bM-^HM-^Fhns/M-bM-^HM-^FstpA from aerobic and anaerobic growth conditions
Investigation of whole genome gene expression level changes in a Escherichia coli MG1655 K-12 M-bM-^HM-^Fhns/M-bM-^HM-^FstpA strain from exponental growth under aerobic and anaerobic growth conditions. The results are further described in the article Genome-scale Analysis of E.coli FNR Reveals the C...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2013-06-20 | E-GEOD-46144 | biostudies-arrayexpress
TranscriptomicsCathepsin K Contributes to Cavitation and Collagen Turnover in Pulmonary Tuberculosis
Cavitation in tuberculosis (TB) enables highly efficient person-to-person aerosol transmission. Currently, a number of hypotheses exist regarding the mechanisms underlying this process. To explore this process, we undertook an unbiased next-generation transcriptional analysis of samples from cavity ...
ORGANISM(S): Oryctolagus cuniculus 
2015-11-03 | E-GEOD-68206 | biostudies-arrayexpress
TranscriptomicsChip-chip from Escherichia coli MG1655 K-12, WT and M-bM-^HM-^Ffnr strains
Mapping the occupancy of FNR, HNS, and IHF throughout the genome of Escherchia coli MG1655 K-12 using an affinity purified antibody under anerobic growth conditions. We also mapped the binding of the M-CM-^_ subunit of RNA Polymerase under both aerobic and anaerobic growth conditions. As a control, ...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2013-06-20 | E-GEOD-41186 | biostudies-arrayexpress
TranscriptomicsDefective K-Ras Oncoproteins Initiate Cancer In Vivo and Evolve to Overcome Impaired Effector Binding
The oncogenic proteins expressed in human cancer cells are exceedingly difficult targets for drug discovery due to intrinsic properties of the Ras GTPase switch. As a result, recent efforts have largely focused on inhibiting Ras-regulated kinase effector cascades, particularly the Raf/MEK/ERK and PI...
ORGANISM(S): Mus musculus 
2011-09-30 | E-GEOD-28687 | biostudies-arrayexpress
TranscriptomicsHigh-throughput Solexa sequencing of total RNA from Escherichia coli wild type and M-bM-^HM-^Ffnr strain (PK4854)
Investigation of whole genome gene expression level changes in a Escherichia coli MG1655 K-12 M-bM-^HM-^Ffnr mutant, compared to the wild-type strain. The mutations engineered into this strain produce a strain lacking the FNR protein. A RNA-seq study using total RNA recovered from two separate cult...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2013-06-20 | E-GEOD-41190 | biostudies-arrayexpress
TranscriptomicsSpecies-specific factors mediate extensive heterogeneity of mRNA 3' ends in yeasts
Most eukaryotic genes express mRNAs with alternative polyadenylation sites at their 3’ ends. Here we show that polyadenylated 3’ termini in three yeast species (S. cerevisiae, K. lactis, D. hansenii) are remarkably heterogeneous. Instead of a few discrete 3’ ends, the average yeast gene has an “en...
ORGANISM(S): Saccharomyces cerevisiae 
2013-07-03 | E-GEOD-47661 | biostudies-arrayexpress
GenomicsCharacterization of attB and core-attP recombination sites of the integrase from Lactobacilus delbrueckii subsp. bulgaricus bacteriophage mv4
Different attB or attP DNA libraries containing 7-bp random nucleotides were used for in vitro recombination mediated by the purified integrase from mv4 bacteriophage against their cognate wild-type attB or attP recombination site.
ORGANISM(S): Lactobacillus delbrueckii subsp. bulgaricus 
2023-12-10 | E-MTAB-13571 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse eGFP/CD3-double positive splenocytes to identify imprinted genes expressed in adult CD3+ splenocytes
Identification of imprinted genes expressed in adult CD3+ splenocytes Experiment Overall Design: For analysis of imprinted gene expression of uniparental-derived cells in adult recipients we chose eGFP/CD3-double positive splenocytes as a defined cell type, and first identified imprinted genes that ...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-6757 | biostudies-arrayexpress
ModelsHockin1999_BloodCoagulation_VaInactivation
Matthew F. Hockin, Kevin M. Cawthern, Michael Kalafatis & Kenneth G. Mann. A model describing the inactivation of factor Va by APC: bond cleavage, fragment dissociation, and product inhibition. Biochemistry 38, 21 (1999). The inactivation of factor Va is a complex process which includes bond cleava...
2024-09-02 | BIOMD0000000365 | BioModels
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