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ProteomicsSubcellular proteomics combined with bioenergetic phenotyping reveals protein biomarkers of respiratory insufficiency in the setting of compromised mitochondrial DNA repair.
The mitochondrial mutator mouse is a well-established model of premature aging in which a progeroid phenotype is driven by the accumulation of somatic mtDNA mutations. Despite evidence of bioenergetic disruption within the cardiac mitochondria, there is little information about the underlying change...
ORGANISM(S): Mus Musculus (mouse) 
2021-01-08 | PXD017000 | JPOST Repository
ProteomicsMitochondrial content normalization using mass spectrometry allows quantitative evaluation of intrinsic bioenergetic efficiency and the underlying proteome across mouse organs.
To separate global changes to metabolism from intrinsic mitochondrial remodeling, investigators commonly use isolated mitochondrial preparations obtained through differential centrifugation. This simple process has been reliably implemented in a variety of tissues to produce intact, functional mitoc...
ORGANISM(S): Mus Musculus (mouse) 
2021-07-09 | PXD020280 | JPOST Repository
ProteomicsMitochondrial proteome of human leuekmia.
Proteome characterization of isolated mitochondria samples prepared from three commonly used acute leukemia cell lines (HL-60, KG-1, MV-4-11). Data were compared to isolated mitochondria prepared from peripheral blood mononuclear cells (PBMC), isolated from healthy human subjects.
ORGANISM(S): Homo Sapiens (human) 
2020-08-04 | PXD020715 | JPOST Repository
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