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TranscriptomicsHepcidin: a key regulator of inflammation
Hepcidin is demonstrated to be the key iron regulatory hormone, produced by the liver. Here we show an unexpected role of hepcidin as a master initiator of the local and systemic inflammatory response. We demonstrated that Hepcidin is a key new essential component of the immune system and may be a p...
ORGANISM(S): Mus musculus 
2021-02-13 | GSE95162 | GEO
TranscriptomicsGut hepcidin: a key regulator of inflammation
Hepcidin is demonstrated to be the key iron regulatory hormone, produced by the liver. Here we show an unexpected role of hepcidin as a master initiator of the local and systemic inflammatory response. We found that hepcidin was highly expressed in the colon of two major idiopathic inflammatory bowe...
ORGANISM(S): Mus musculus 
2019-02-14 | GSE71073 | GEO
TranscriptomicsDefining key transcriptional regulators of extravillous trophoblast differentiation [RNA-seq]
During early human pregnancy, extravillous trophoblasts (EVT) play a central role in placental anchorage and blood vessel remodeling. Despite the essential roles in pregnancy, key factors and mechanisms underlying EVT differentiation remain largely unknown. Here, we defined key transcription factors...
ORGANISM(S): Homo sapiens 
2024-01-16 | GSE212266 | GEO
GenomicsDefining key transcriptional regulators of extravillous trophoblast differentiation [ChIP-seq]
During early human pregnancy, extravillous trophoblasts (EVT) play a central role in placental anchorage and blood vessel remodeling. Despite the essential roles in pregnancy, key factors and mechanisms underlying EVT differentiation remain largely unknown. Here, we defined key transcription factors...
ORGANISM(S): Homo sapiens 
2024-01-16 | GSE212265 | GEO
TranscriptomicsKey transcriptional regulators in Wilms tumors of blastemal subtype
The aim of the study was to identify key transcriptional regulators that might be responsible for the increased resistance to chemotherapy of blastemal Wilms tumors.
ORGANISM(S): Homo sapiens 
2020-04-28 | GSE98334 | GEO
TranscriptomicsTranscriptome analysis reveals key dysregulated transcriptional programmes in uveal melanoma
In this study, we conducted whole-transcriptome sequencing in five primary Uveal Melanoma and four adjacent tissues to uncover key dysregulated the gene-regulatory circuits in Uveal Melanoma.
ORGANISM(S): Homo sapiens 
2023-11-08 | GSE211763 | GEO
TranscriptomicsC/EBPδ drives key endocrine signals in human fetal membranes at parturition
Amnion-derived prostaglandin E2 (PGE2) and cortisol are key to labor onset. Identification of the common transcription factor driving the expression of both cyclooxygenase-2 (COX-2) and 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1), the key enzymes in their production, may hold the key to the treatm...
ORGANISM(S): Homo sapiens 
2021-07-15 | GSE166320 | GEO
TranscriptomicsCorrelation of the expression of the key enzymes and the yield of the lipid
Characterization of the expression of the key enzymes during the growth of Chlorella minutissima UTEX2341
ORGANISM(S): Neodesmus pupukensis 
2016-11-13 | GSE63240 | GEO
TranscriptomicsLarge-scale, quantitative proteomics reveals key proteins required for planarian regeneration initiation
Multi-omics studies are increasingly used to decipher the mechanisms underlying tissue regeneration. However, the use of proteomics for such studies has been limited due to the high cost and relatively low throughput and reproducibility. The genes required for planarian regeneration have primarily b...
ORGANISM(S): Schmidtea mediterranea 
2025-05-18 | GSE232894 | GEO
TranscriptomicsIntegrative Analysis Identifies Key Molecular Signatures Underlying Neurodevelopmental Deficits in Fragile X Syndrome
We report the generation of isogenic hPSC model of FXS and characterize the neurodevelopmental capacity of these cells, performed transcriptome profiling in FXS neurons and identified key pathways
ORGANISM(S): Homo sapiens 
2020-05-24 | GSE117248 | GEO
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