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ProteomicsTime-Dependent Effects of Anesthetic Administration on the Rat Hypothalamus and Cerebral Cortex Peptidome
Prohormone-derived neuropeptides act as cell-cell signaling molecules to mediate a wide variety of biological processes in the animal brain. Mass spectrometry-based peptidomic experiments are valuable approaches to gain insight into the dynamics of individual peptides under different physiological c...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-10-25 | PXD043738 | Pride
Keywords peptidomics Hypothalamus Neuropeptides Anesthetics Cerebral cortex 
TranscriptomicsHeart-muscle expression ratios in pig obtained by 454-sequencing, iTRAQ-based proteomics and cDNA microarrays
The recent development within high-throughput technologies for expression profiling has allowed for parallel analysis of transcriptomes and proteomes in biological systems such as comparative analysis of transcript and protein levels of tissue regulated genes. Until now, such studies of have only in...
ORGANISM(S): Sus scrofa 
2009-01-22 | E-GEOD-10122 | biostudies-arrayexpress
ProteomicsUnraveling the Global Proteome and Phosphoproteome of Prostate Cancer Patient-Derived Xenografts
Resistance to androgen deprivation therapies leads to metastatic castration-resistant prostate cancer (mCRPC) of adenocarcinoma (AdCa) origin that can transform to emergent aggressive variant prostate cancer (AVPC) which has neuroendocrine (NE)-like features. To this end, we used LuCaP patient-deriv...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-06-09 | MSV000092139 | MassIVE
TranscriptomicsResponse of muscle to stress
As muscle function is relevant for the stress response, and as gene array and proteomics analyses have not been conducted to investigate muscle response in stress paradigm in birds, we developed generic approaches to assess molecular bases of muscle response to stress in chicken. Restraint test was ...
ORGANISM(S): Gallus gallus 
2010-06-05 | E-GEOD-19644 | biostudies-arrayexpress
TranscriptomicsHIT analysis of T cells activated in the presence of TGF-β
We have developed a multi-analyte fluid-phase protein array technology termed high-throughput immunophenotyping using transcription (HIT). This method employs a panel of monoclonal antibodies, each tagged with a unique oligonucleotide sequence that serves as a molecular barcode. After staining a s...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-10762 | biostudies-arrayexpress
TranscriptomicsKCl Stress in Desulfovibrio vulgaris Hildenborough (Series 1)
Increased salinity constitutes an important and frequent fluctuation faced by D. vulgaris in its natural habitat. Using data from microarray experiments, we investigated the effects of excess KCl on D. vulgaris. Keywords: stress response, time course Comparison of cells treated with 250mM KCl to unt...
ORGANISM(S): Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough 
2010-06-11 | E-GEOD-4515 | biostudies-arrayexpress
TranscriptomicsHIT T cell versus B cell line proof-of-principle
We have developed a multi-analyte fluid-phase protein array technology termed high-throughput immunophenotyping using transcription (HIT). This method employs a panel of monoclonal antibodies, each tagged with a unique oligonucleotide sequence that serves as a molecular barcode. After staining a s...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-10761 | biostudies-arrayexpress
TranscriptomicsMolecular variability of FLT3/ITD mutants and their impact on the differentiation program of 32D cells
FLT3 is the most frequently mutated gene in AML – up to 40% of AML harbor an activating mutation within FLT3 gene. Though AML is a relatively rare disease, such a high mutability rate, as observed with FLT3 gene, is striking. To elucidate the molecular background of this phenomenon, we have establ...
ORGANISM(S): Mus musculus 
2010-04-08 | E-GEOD-12766 | biostudies-arrayexpress
TranscriptomicsTranscriptomic, proteomic and metabolomic analysis of UV-B signaling in maize
This study looked for signals produced in UV-B irradiated leaves, and possibly induced in shielded leaves, that modulate physiological responses in maize. Transcriptome and proteomics profiling tracked changes in exposed and shielded organs. Metabolic profiling was examined for signaling molecules...
ORGANISM(S): Zea mays 
2011-02-01 | E-GEOD-25038 | biostudies-arrayexpress
TranscriptomicsIntramuscular fat variability in pigs
Intramuscular (i.m.) fat content influencing consumer’s acceptability of pork is considered as a limiting factor for meat quality. To gain insight into the biological basis of individual variability in i.m. fat content, both gene expression profiling and proteomic investigation were associated in ...
ORGANISM(S): Sus scrofa 
2010-05-07 | E-GEOD-10759 | biostudies-arrayexpress
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