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TranscriptomicsThe effect of nicotinamide on dysregulated genes associated with frataxin deficiency in FRDA.
To investigate the efficacy of nicotinamide treatment using our ex-vivo primary lymphocyte model, we performed high-throughput RNA sequencing on libraries generated from untreated and nicotinamide treated samples. PBMC isolated from FRDA affected individuals were cultured to prepare the primary lymp...
ORGANISM(S): Homo sapiens 
2013-04-03 | E-GEOD-42960 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of fission yeast wild type and Pab2 knockout strains to invstigate the role of Pab2 in synthesis of noncoding snoRNAs
Here we used DNA microarrays to identify hyperadenylated transcripts detected in pab2 cells. Using this genome-wide approach, we found that the absence of Pab2 leads to the accumulation of polyadenylated snoRNAs and we describe the molecular mechanism of their accumulation.
ORGANISM(S): Schizosaccharomyces pombe 
2010-01-21 | E-TABM-843 | biostudies-arrayexpress
TranscriptomicsDetermination of the spatial organization of the FXN gene locus by using Chromosome Conformation Capture technique coupled with High-throughtput sequencing (3C-seq).
Accumulating data from different groups have demonstrated that alteration of post-translational histone modifications is an important underlying mechanism for FXN silencing in FRDA. The relationship between chromatin architecture and histone modification marks in the FXN gene locus is likely to be i...
ORGANISM(S): Homo sapiens 
2013-12-16 | E-GEOD-42961 | biostudies-arrayexpress
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