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TranscriptomicsTranscription profiling of mouse retina with ectopic expression of NR2E3 in Nrl-/- animals reveals in vivo function of NR2E3 in establishing photoreceptor identity during mammalian retinal development
Rod and cone photoreceptors in mammalian retina are generated from common pool(s) of neuroepithelial progenitors. NRL, CRX and NR2E3 are key transcriptional regulators that control photoreceptor differentiation. Mutations in NR2E3, a rod-specific orphan nuclear receptor, lead to loss of rods, incr...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5338 | biostudies-arrayexpress
TranscriptomicsGene profiling of Müller glia during early stages of zebrafish photoreceptor regeneration
Photoreceptor damage in adult mammals results in permanent cell loss and glial scarring in the retina. In contrast, adult zebrafish can regenerate photoreceptors following injury. By using a stable transgenic line in which GFP is driven by the cis-regulatory sequences of a glial specific marker gfap...
ORGANISM(S): Danio rerio 
2009-02-04 | E-GEOD-14495 | biostudies-arrayexpress
TranscriptomicsDistinct signature of altered homeostasis in aging rod photoreceptors: Implications for retinal diseases
To better understand the mechanistic basis of aging and its relationship with retinal degeneration, we examined gene expression changes in aging rod photoreceptors. Rod photoreceptor cell death is a feature of normal retinal aging and is accelerated in many retinal degenerative diseases, including A...
ORGANISM(S): Mus musculus 
2010-06-14 | E-GEOD-22317 | biostudies-arrayexpress
TranscriptomicsGlobal expression profiling of peripheral Qa-1 class Ib-restricted CD8aa+TCRab+ regulatory T Cells reveals innate-like features: implications for immune regulatory repertoire
To better understand the function of CD8aa Tregs, we have recently characterized several CD8aa+TCRab+ T cell clones and lines that are physiologically primed and are involved in recovery and protection from EAE (REF). In this report, we present a comparison of global gene expression patterns in CD8a...
ORGANISM(S): Mus musculus 
2011-08-31 | E-GEOD-22985 | biostudies-arrayexpress
TranscriptomicsA role for Prenylated rab acceptor 1 in vertebrate photoreceptor development
The rd1 mouse retina is a well-studied model of retinal degeneration where rod photoreceptors undergo cell death beginning at postnatal day P10 until P21. This period coincides with photoreceptor terminal differentiation in a normal retina. We have used the rd1 retina as a model to investigate early...
ORGANISM(S): Mus musculus 
2012-11-02 | E-GEOD-41821 | biostudies-arrayexpress
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