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TranscriptomicsBromodomain-dependent stage-specific male genome programming by Brdt [Illumina BeadArray]
Male germ cell differentiation is a highly regulated multistep process initiated by the commitment of progenitor cells into meiosis and characterized by major chromatin reorganizations in haploid spermatids. We report here that a single member of the double bromodomain BET factors, Brdt, is a master...
ORGANISM(S): Mus musculus 
2012-08-30 | E-GEOD-39909 | biostudies-arrayexpress
GenomicsIdentification of 67 histone marks and histone lysine crotonylation as a new type of histone modification
We report the identification of 67 previously undescribed histone modifications, increasing the current number of known histone marks by about 70%. We further investigated one of the marks, lysine crotonylation (Kcr), confirming that it represents an evolutionarily-conserved histone posttranslationa...
ORGANISM(S): Mus musculus 
2011-10-06 | E-GEOD-32663 | biostudies-arrayexpress
GenomicsBromodomain-dependent stage-specific male genome programming by Brdt [ChIP-Seq]
Male germ cell differentiation is a highly regulated multistep process initiated by the commitment of progenitor cells into meiosis and characterized by major chromatin reorganizations in haploid spermatids. We report here that a single member of the double bromodomain BET factors, Brdt, is a master...
ORGANISM(S): Mus musculus 
2012-08-30 | E-GEOD-39908 | biostudies-arrayexpress
TranscriptomicsDual targeting of MYC and CYCLON by BET bromodomain inhibition optimizes Rituximab response in lymphoma.
Immuno-chemotherapy regimens elicit high response rates in B-cell non-Hodgkin lymphoma but heterogeneity in response duration is observed, with some patients achieving cure and others showing refractory disease or relapse. Using a transcriptome-powered targeted proteomics screen, we discovered a gen...
ORGANISM(S): Homo sapiens 
2013-06-01 | E-GEOD-46873 | biostudies-arrayexpress
TranscriptomicsAtad2 is a generalist facilitator of chromatin dynamics in embryonic stem cells [Microarray transcriptomic analysis]
Although the conserved AAA ATPase – bromodomain factor, ATAD2, has been described as a transcriptional co-activator upregulated in many cancers, its function remains poorly understood. Here, using a combination of ChIP-seq, ChIP-proteomics and RNA-seq experiments in embryonic stem cells, we found ...
ORGANISM(S): Mus musculus 
2016-03-24 | E-GEOD-69899 | biostudies-arrayexpress
Transcriptomics"Off-context" gene expression in lung cancer identifies a group of metastatic-prone tumors
An unexplored consequence of epigenetic alterations associated with cancer is the ectopic expression of tissue-restricted genes. Here, a new strategy was developed to decipher genome-wide expression data in search for these “off-context” gene activations, which consisted first, in identifying a larg...
ORGANISM(S): Homo sapiens 
2013-05-24 | E-GEOD-30219 | biostudies-arrayexpress
TranscriptomicsA specific CBP/p300-dependent gene expression program drives the metabolic remodelling in late stages of spermatogenesis.
Histone hyperacetylation is thought to drive the replacement of histones by transition proteins that occurs in elongating spermatids after a general shut-down of transcription. The molecular machineries underlying this histone hyperacetylation remain still undefined. Here we focused our attention on...
ORGANISM(S): Mus musculus 
2014-03-12 | E-GEOD-55767 | biostudies-arrayexpress
TranscriptomicsChromatin-to-nucleoprotamine transition is controlled by the histone H2B variant TH2B [Illumina]
The conversion of male germ cell chromatin to a nucleoprotamine structure is fundamental to the life cycle yet the underlying molecular details remain obscure. Here we show that an essential step is the genome-wide incorporation of TH2B, a histone H2B variant of hitherto unknown function. Using mous...
ORGANISM(S): Mus musculus 
2013-10-17 | E-GEOD-46136 | biostudies-arrayexpress
TranscriptomicsReceptor-independent ectopic activity of PROLACTIN predicts aggressive lung tumors and indicates HDACi-based therapeutic strategies.
Aim: PROLACTIN (PRL), normally produced by the pituitary gland, acts through its receptor (PRL-R) to initiate a signalling cascade to the genome. PRL can also be produced by cancer cells and become oncogenic by stimulating its receptor following an autocrine or paracrine route. Here we investigated ...
ORGANISM(S): Homo sapiens 
2014-08-05 | E-GEOD-49544 | biostudies-arrayexpress
GenomicsChromatin-to-nucleoprotamine transition is controlled by the histone H2B variant TH2B [ChIP-Seq]
The conversion of male germ cell chromatin to a nucleoprotamine structure is fundamental to the life cycle yet the underlying molecular details remain obscure. Here we show that an essential step is the genome-wide incorporation of TH2B, a histone H2B variant of hitherto unknown function. Using mous...
ORGANISM(S): Mus musculus 
2013-10-18 | E-GEOD-45915 | biostudies-arrayexpress
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