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MetabolomicsIntegration of magnetic resonance imaging and protein and metabolite CSF measurements to enable early diagnosis of secondary progressive multiple sclerosis

Molecular networks in neurological diseases are complex. Despite this fact, contemporary biomarkers are in most cases interpreted in isolation, leading to a significant loss of information and power. We present an analytical approach to scrutinize and combine information from biomarkers originati...

2018-08-13 | MTBLS558 | MetaboLights
ProteomicsSystematic Analysis of the Cerebrospinal Fluid Proteome of Fibromyalgia patients
Fibromyalgia (FM) is a syndrome characterized by widespread muscular pain, fatigue and functional symptoms, which is known to be difficult to diagnose as the various symptoms overlap with many other conditions. Currently, there are no biomarkers for FM, and the diagnosis is made subjectively by the ...
ORGANISM(S): Homo sapiens (Human) 
2018-04-25 | PXD008076 | Pride
Fibromyalgia Lc-ms Csf Biomarker 
ProteomicsHuman temporal neocortex brain LC-MS
We used label-free shotgun mass spectrometry to analyze temporal neocortex samples from AD brain, other neurological disorders and non-demented controls, in order to identify additional proteins thatare altered in AD. The mass spectrometry results were then verified by antibody suspension bead arra...
ORGANISM(S): Homo sapiens (Human) 
2016-09-29 | PXD004499 | Pride
Alzheimer’s disease  mass spectrometry  antibodies Immobilized/chemistry  extracellular vesicles  exosomes  exocytosis  endocytosis. 
ProteomicsHuman temporal neocortex brain LC-MS
We used label-free shotgun mass spectrometry to analyze temporal neocortex samples from AD brain, other neurological disorders and non-demented controls, in order to identify additional proteins thatare altered in AD. The mass spectrometry results were then verified by antibody suspension bead arra...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-26 | MSV000081016 | MassIVE
MetabolomicsDisease phenotype prediction in multiple sclerosis

Progressive multiple sclerosis (PMS) is currently diagnosed retrospectively. Here, we work towards a set of biomarkers that could assist in early diagnosis of PMS. A selection of cerebrospinal fluid metabolites (n=15) was shown to differentiate between PMS and its preceding phenotype in an indepe...

2023-05-31 | MTBLS1464 | MetaboLights
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