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TranscriptomicsAlternative Isoform Regulation in Human Tissue Transcriptomes
Through alternative processing of pre-mRNAs, individual mammalian genes often produce multiple mRNA and protein isoforms that may have related, distinct or even opposing functions. Here we report an in-depth analysis of 15 diverse human tissue and cell line transcriptomes based on deep sequencing of...
ORGANISM(S): Homo sapiens 
2008-09-30 | E-GEOD-12946 | biostudies-arrayexpress
TranscriptomicsDeep Sequence Analysis of the Relationship between Gene Expression, CpG Island Methylation, and Gene Copy Number in Breast Cancer Cells
We used deep sequencinge technology to profile the transcriptome, gene copy number, and CpG island methylation status simultaneously in eight commonly used breast cell lines to develop a model for how these genomic features are integrated in estrogen receptor positive (ER+) and negative breast cance...
ORGANISM(S): Homo sapiens 
2011-03-16 | E-GEOD-27003 | biostudies-arrayexpress
TranscriptomicsStructural annotation of equine protein-coding genes determined by mRNA sequencing
The horse, like a majority of animal species, has a limited amount of species-specific expressed sequence data available in public databases. As a result, structural models for a majority of genes defined in the equine genome are predictions based on ab initio sequence analysis or the projection of...
ORGANISM(S): Equus caballus 
2010-11-10 | E-GEOD-21925 | biostudies-arrayexpress
TranscriptomicsRNA-seq of rat dorsal root ganglia after ligation to investigate central nervous system transcriptomics in chronic pain using agnostic splice site discovery methods
The study pursued dual goals: To advance mRNA-seq bioinformatics towards unbiased transcriptome capture and to demonstrate its potential for discovery in neuroscience by applying the approach to an in vivo model of neurological disease. We found that 12.4% of known genes were induced and 7% were sup...
ORGANISM(S): Rattus norvegicus 
2010-05-01 | E-GEOD-20895 | biostudies-arrayexpress
TranscriptomicsAnalysis of the Equine Transcriptome by mRNA Sequencing
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Equus caballus 
2013-05-13 | E-GEOD-46859 | biostudies-arrayexpress
UnknownAlternative isoform regulation in human tissue transcriptomes.
Not available
S-EPMC2593745 | biostudies-literature
UnknownMPSS profiling of human embryonic stem cells.
Not available
S-EPMC514702 | biostudies-literature
GenomicsAltered DNA Methylation Patterns in Human Oral Squamous Cell Carcinoma Cells
To gain insight into the DNA methylation changes during OSCC carcinogenesis, we utilized cytosine conversion and next generation sequencing based technique- enhanced reduced representation bisulfite sequencing (ERRBS) - to assess DNA methylation in cultured, human TERT-immortalized, non-tumorigeni...
ORGANISM(S): Homo sapiens 
2014-10-28 | E-GEOD-51752 | biostudies-arrayexpress
UnknownDiametrically opposite methylome-transcriptome relationships in high- and low-CpG promoter genes in postmitotic neural rat tissue.
Not available
S-EPMC3368807 | biostudies-literature
UnknownFull-length mRNA-Seq from single-cell levels of RNA and individual circulating tumor cells.
Not available
S-EPMC3467340 | biostudies-literature
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