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ProteomicsProteomics of human peripheral blood mononuclear cells under normal circadian cycle and under a simulated night shift
Proteomic data from human peripheral blood mononuclear cells (PBMCs). Samples taken over a 24 hour constant light and diet following 3 days of normal day shift cycle or a night shift - circadian misaligned schedule where sleep and wake cycles were reversed. Time points (in clock time) 1, 7, 14, 21 h...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-10-05 | MSV000093054 | MassIVE
TranscriptomicsModeling Inducible Human Tissue Neoplasia Identifies an ECM Interaction Network Involved in Cancer Progression
To elucidate mechanisms of cancer progression, we generated inducible human neoplasia in 3-dimensionally intact epithelial tissue. Gene expression profiling of both epithelia and stroma at specific time points during tumor progression revealed sequential enrichment of genes mediating discrete biolog...
ORGANISM(S): Mus musculus 
2009-06-02 | E-GEOD-15299 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of XX and XY sorted mouse somatic support cells and XX and XY mouse whole gonads to identify potential new mammalian gonadal sex determining genes.
Gonadal sex determining (GSD) genes that initiate fetal ovarian and testicular development and differentiation are expressed in the cells of the urogenital ridge that differentiate as somatic support cells (SSCs), i.e., granulosa cells of the ovary and Sertoli cells of the testis. To identify potent...
ORGANISM(S): Mus musculus 
2007-11-30 | E-GEOD-4928 | biostudies-arrayexpress
TranscriptomicsGenomic characterization of intrinsic and acquired resistance to cetuximab in colorectal cancer patients
Anti-EGFR antibodies are effective in therapies for late-stage colorectal cancer (CRC); however, many tumours are unresponsive or develop resistance. We performed genomic analysis of intrinsic and acquired resistance to anti-EGFR therapy in prospectively collected tumour samples from 25 CRC patients...
ORGANISM(S): Homo sapiens 
2019-09-21 | E-MTAB-8340 | biostudies-arrayexpress
TranscriptomicsExpression data from exponentially proliferating ovarian cancer cell lines
We used microarrays to assess gene expression in proliferating ovarian cancer cell lines Ovarian cancer cell lines were plated and harvested when 50-80% confluent. RNA was extracted and hybridized on Affymetrix microarrays. At least 3 biological repeats were performed for each cell line.
ORGANISM(S): Homo sapiens 
2013-01-26 | E-GEOD-43765 | biostudies-arrayexpress
GenomicsGenotype - samples
PNET genotyping
EGAD00010000260 | EGA
GenomicsMolecular Sub-grouping of CNS-PNET
In our study we aimed to define CNS-PNET subgroups. We performed Expression, Genotyping and/or Immunohistochemistry on 142 samples from 20 worldwide centers. Using these techniques, we have identified three molecular subgroups with distinct expression and copy number patterns, as well as, unique c...
EGAS00000000116 | EGA
GenomicsAnnie Huang and the Hospital for Sick Children
Data Access Committee EGAC01000000015
EGAC01000000015 | EGA
ProteomicsSingle-cell signaling analysis reveals that Major Vault Protein facilitates RasG12C inhibitor resistance
Recently developed covalent inhibitors for RasG12C provide the first pharmacological tools to target mutant Ras-driven cancers. However, the rapid development of resistance to current clinical Ras G12C inhibitors is common. Presumably, a subpopulation of RasG12C-expressing cells adapt their signalin...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-05-16 | MSV000094779 | MassIVE
TranscriptomicsRole of Aldoketoreductases and Other Doxorubicin Pharmacokinetic Genes in Doxorubicin Resistance, DNA binding, and Subcellular Localization
Objective: To assess the role of aldoketoreductases and other doxorubicin pharmacokinetic or pharmacogenomic genes in doxorubicin cytotoxicity, resistance, DNA binding activity, and subcellular localization, Methods: We conducted a whole genome microarray study to identify differences in betwee...
ORGANISM(S): Homo sapiens 
2012-11-22 | E-GEOD-27254 | biostudies-arrayexpress
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