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ProteomicsKi-67 organises heterochromatin during cell proliferation
Antigen Ki-67 is a nuclear protein expressed in proliferating mammalian cells. It is widely used in cancer histopathology but its functions remain unclear. Here, we show that Ki-67 controls heterochromatin organisation. Altering Ki-67 expression levels did not significantly affect cell proliferation...
ORGANISM(S): Homo sapiens (Human) 
2018-10-26 | PXD003551 | Pride
Ki-67 interactome Cell proliferation Heterochromatin Mki67 Antigen ki-67 
ProteomicsKi-67 is necessary during DNA replication for forks protection and genome stability
Ki-67 molecular functions and properties have remained quite obscure for a long time, despite its importance as a major proliferation marker in clinic. Only recently it has been shown that Ki-67 has a major role in the formation of the mitotic chromosome periphery compartment, and it is a protein ph...
ORGANISM(S): Homo sapiens (Human) 
2024-04-13 | PXD037513 | Pride
Ki-67 Silac Genome stability Cell cycle Dna replication 
TranscriptomicsRNA sequencing from publication: Ki-67 is necessary during DNA replication for forks protection and genome stability
Ki-67 is highly expressed in proliferating cells, characteristic that made the protein a very important marker widely used in the clinic. However, its molecular functions and properties have remained quite obscure for a long time. Only recently important discoveries have shed some light on Ki-67 fun...
ORGANISM(S): Homo sapiens 
2024-04-07 | E-MTAB-12279 | biostudies-arrayexpress
GenomicsHuman HeLa cells: Control shRNA vs Ki-67 shRNA, in vitro and xenografts
Human HeLa cells: Control shRNA vs Ki-67 shRNA, in vitro and xenografts
PRJNA681603 | ENA
GenomicsRaw RNA-seq data from control and Ki-67-depleted HCT116 human colon cancer cells
Raw RNA-seq data from control and Ki-67-depleted HCT116 human colon cancer cells
PRJNA667851 | ENA
TranscriptomicsHuman HeLa cells: Control shRNA vs Ki-67 shRNA, in vitro and xenografts
Transcriptional profiling of isogenic human cervical cancer cell line HCT-116, comparing cells treated with control shRNA or with Ki-67 shRNA, grown either in vitro or as tumours in nude mice. The aim was to assess effects of loss of Ki-67 on gene expression during exponential cell growth and in tum...
ORGANISM(S): Homo sapiens 
2021-02-18 | GSE162365 | GEO
UnknownKi-67 gene expression.
Not available
S-EPMC8629999 | biostudies-literature
GenomicsRNA sequencing from publication: Ki-67 is necessary during DNA replication for forks protection and genome stability
RNA sequencing from publication: Ki-67 is necessary during DNA replication for forks protection and genome stability
PRJEB56643 | ENA
TranscriptomicsRaw RNA-seq data from control and Ki-67-depleted HCT116 human colon cancer cells
Raw RNA-seq data from control and Ki-67-depleted HCT116 human colon cancer cells
ORGANISM(S): Homo sapiens 
2021-07-23 | GSE159160 | GEO
UnknownThe cell proliferation antigen Ki-67 organises heterochromatin.
Not available
S-EPMC4841783 | biostudies-literature
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