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MetabolomicsMicrobial tryptophan metabolism orchestrated by trilobatin through TPH1 activation protects against acute kidney injury
Background: Acute kidney injury (AKI) remains a major clinical challenge with limited therapeutic options. Gut microbiota dysbiosis plays a crucial role in the pathogenesis of AKI. Trilobatin (TLB), has been previously reported to modulate gut microbiota and exert neuroprotective effects; however, i...
2026-04-05 | MTBLS14222 | MetaboLights
MetabolomicsIntegrated transcriptome-metabolome analysis reveals attenuated combined toxicity: Antagonistic interactions of three thermal processing contaminants in murine kidney-urine systems

To investigate the toxicological effects after individual or combined sub-chronical exposure to oxidized triacylglycerols, aldehydes, and 3-MCPDE formed during thermal processing of high-fat foods, this study implemented transcriptome-metabolome analysis of renal tissues in Kunming mice, suppleme...

2026-02-25 | MTBLS13934 | MetaboLights
MetabolomicsDysregulation of the 3β-Hydroxysteroid Dehydrogenase Type 2 Enzyme and Steroid Hormone Biosynthesis in Chronic Kidney Disease

Chronic kidney disease (CKD) presents a critical global health challenge, marked by the progressive decline of renal function. This study explores the role of the 3β-hydroxysteroid dehydrogenase type 2 enzyme (HSD3B2) and steroid hormone biosynthesis pathway in CKD pathogenesis and progression. U...

2024-10-10 | MTBLS10715 | MetaboLights
MetabolomicsCyclooxygenase-2, Asymmetric Dimethylarginine, and the Cardiovascular Hazard From Nonsteroidal Anti-Inflammatory Drugs (Murine kidney and plasma UPLC-MS/MS assay)

BACKGROUND: Large-scale, placebo-controlled trials established that nonsteroidal anti-inflammatory drugs confer a cardiovascular hazard: this has been attributed to depression of cardioprotective products of cyclooxygenase (COX)-2, especially prostacyclin. An alternative mechanis...

2019-08-22 | MTBLS680 | MetaboLights
MetabolomicsClinical features and Multiomics Profiles Indicate Coagulation and Platelet Dysfunction as Key Pathological Pathways in COVID-19 Viral Sepsis
Background: The role of viral infections as a mediator of systemic immune dysfunction leading to sepsis has received limited attention compared to the bacterial pathogens. The COVID-19 pandemic and the increased cases of sepsis in the absence of known bacterial pathogens have highlighted the clinica...
2025-12-05 | MTBLS9664 | MetaboLights
ProteomicsSirtuin 5 Reduces Malonylation in Non-mitochondrial Metabolic Pathways in Diabetic Kidney Disease
Early diabetic kidney disease (DKD) is marked by dramatic metabolic reprogramming due to nutrient excess, mitochondrial dysfunction, and increased renal energy requirements from hyperfiltration. We hypothesized that changes in metabolism in DKD may be regulated by Sirtuin 5 (SIRT5), a deacylase that...
ORGANISM(S): Mus Musculus 
2023-06-26 | PXD037819 | panorama
ProteomicsGlobal proteome and phosphoproteome characterization of sepsis-induced kidney injury
Sepsis-induced acute kidney injury (S-AKI) is the most common complication in hospitalized and critically ill patients, highlighted by a rapid decline of kidney function occurring a few hours or days after sepsis onset. Systemic inflammation elicited by microbial infections is believed to lead to ki...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
MSV000086126 | MassIVE
TranscriptomicsExpression data from Human Kidney (HK) samples
Males are 50% more likely to develop end stage kidney failure compared to women. In this study we wanted to find out the molecular mechanism responsible for this increased risk. We collected kidney samples from patients with and without kidney disease and performed a comprehensive gene expression an...
ORGANISM(S): Homo sapiens 
2010-04-13 | E-GEOD-12682 | biostudies-arrayexpress
ProteomicsERR agonism reverses mitochondrial dysfunction and inflammation in the aging kidney
A gradual decline in renal function occurs even in healthy aging individuals. In addition to aging per se, concurrent metabolic syndrome and hypertension, which are common in the aging population, can induce mitochondrial dysfunction, and inflammation, which collectively contribute to age-related ki...
ORGANISM(S): Mus musculus (Mouse) 
2023-08-02 | PXD020051 | Pride
Mitochondrial Aging Err Kidney 
ProteomicsBrain death associated activation of Calpain-Talin axis in donor kidneys underlies podocyte matrix degradation and graft dysfunction in kidney transplantation
Deceased kidney donation after brain death (DBD) is the main source of transplants, yet these grafts yield inferior transplant outcomes when compared to living donation. In brain death, cerebral injury contributes to systemic biological dysregulation, causing significant cellular stress in donor kid...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD022074 | Pride
Kidney cytoskeleton Podocytes Donation after brain death (dbd) Protein degradation Allograft dysfunction Kidney transplantation 
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