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MetabolomicsMetabolomics of SLE-associated podocytes
To characterize metabolic changes in SLE-associated podocytes, 1 × 10^6 podocytes were stimulated for 24 hours with immune complexes (ICs) isolated from patients with systemic lupus erythematosus (SLE) or with IgG from healthy donors as a control. The cells were then collected and analyzed by untarg...
2026-09-23 | MTBLS15778 | MetaboLights
TranscriptomicsDifferentiation of human amniotic fluid kidney progenitor cells into podocytes and comparison with human conditionally immortalized podocytes
In this work, we isolated and characterized a novel cell population derived from human amniotic fluid cells (hAKPC-P), and we differentiated them into podocytes. We used microarrays to study global changes in gene expression before and after differentiation in hAKPC-P and human immortalized podocyte...
ORGANISM(S): Homo sapiens 
2013-12-19 | E-GEOD-49439 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse Podocytes reveal use of FcRn to clear IgG from the glomerular basement membrane
The glomerular filtration barrier prevents large serum proteins from being lost into the urine. It is not known, however, why the filter does not routinely clog with large proteins that enter the glomerular basement membrane (GBM). Here we provide evidence that an active transport mechanism exists t...
ORGANISM(S): Mus musculus 
2008-06-11 | E-GEOD-10017 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of human iPSC derived podocytes
The gene expression profile of human iPSC derived podocytes were analyzed by utilizing NEPHS1-GFP knock-in human iPS cell line. The induced podocytes shows characteristic gene expression pattern that overlap with those of mouse and human podocytes in vivo. Kidney tissue was induced from human iPSC b...
ORGANISM(S): Homo sapiens 
2015-11-24 | E-GEOD-66969 | biostudies-arrayexpress
TranscriptomicsEffect of Growth hormone on podocytes
Transcriptome analysis of growth hormone dependant genes in glomerular podocytes Differentiated human glomerular podocytes in culture exposed to growth hormone for 0 min, 2 min, 5 min, 15 min, and 30 min. Total RNA is extracted and subjected to microarray analysis.
ORGANISM(S): Homo sapiens 
2010-10-01 | E-GEOD-21327 | biostudies-arrayexpress
ProteomicsComparative protein profiling of wild type and zyxin knockout podocytes
Podocyte detachment due to mechanical stress is a common issue in hypertension-induced kidney disease. The present study investigated the role of zyxin in mechanically stretched podocytes, a model for glomerular hypertension. Conditionally immortalized differentiated podocytes were seeded on flexibl...
ORGANISM(S): Mus musculus (Mouse) 
2024-04-30 | PXD050861 | Pride
Podocytes Zyxin knockout Mechanical stretch Lc-ms/ms 
TranscriptomicsGenome wide mapping of H3K27me3 in differentiated mouse podocytes
We explored H3K27me3 binding sites in the genome of differentiated, conditionally immortalized mouse podocytes. Cells were allowed to differentiate for 14 days, following thermoshifting, before treatment with either vehicle (DMSO) or the S-adenosylhomocysteine hydrolase inhibitor 3-deazaneplanocin ...
ORGANISM(S): Mus musculus 
2015-12-09 | E-GEOD-69610 | biostudies-arrayexpress
GenomicsGenome wide map of long noncoding RNA Tug1 binding sites in cultured mouse podocytes
We generated a genome wide map of instances where the long noncoding RNA, Tug1, binds to DNA in cultured mouse podocytes under normal glucose conditions using Chromatin-RNA Precipitation coupled with high throughput sequencing (ChIRP-Seq) 48 alternating (even, odd) biotynilated probes were designed ...
ORGANISM(S): Mus musculus 
2016-10-24 | E-GEOD-77493 | biostudies-arrayexpress
TranscriptomicsDeep RNA Sequencing of native mouse podocytes and non-podocytes glomerular cells
Purpose: Next-generation sequencing (NGS) was used to define the transcriptome of native mouse podocytes and non-podocytes glomerular cells as part of a project aiming to define the molecular fingerprint of mouse podocytes. Method: Glomeruli from 29 Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/J x hNPHS...
ORGANISM(S): Mus musculus 
2019-01-01 | E-MTAB-5457 | biostudies-arrayexpress
ProteomicsIRE1alpha promotes reticulophagy in podocytes
Protomics data for "IRE1alpha promotes reticulophagy in podocytes"
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-03-10 | MSV000089032 | MassIVE
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