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Metabolomicstargeted metabolomics of rat's kidney
Podophyllotoxin (PPT) exhibits limited clinical utility due to its nephrotoxicity, and its underlying mechanisms remain poorly understood. This study employs the toxicological evidence chain (TEC) framework and integrated multi-omics analyses to investigate the potential involvement of the microbiot...
2026-06-28 | MTBLS14869 | MetaboLights
MetabolomicsPP2Cm Dysregulation Is Associated with Impaired BCAA Catabolism and cGAS-STING Activation in Diabetic Kidney Disease
Background and Aims:Branched-chain amino acids (BCAAs) are increasingly implicated in diabetic kidney disease (DKD), yet the role of protein phosphatase 2C mitochondrial (PP2Cm), encoded by PPM1K and regulating BCAA catabolism through the branched-chain α-ketoacid dehydrogenase (BCKDH) complex, rema...
2026-10-09 | MTBLS15967 | MetaboLights
MetabolomicsER stress inhibits liver fatty acid oxidation while unmitigated stress leads to anorexia-induced lipolysis and both liver and kidney steatosis
The unfolded protein response (UPR), induced by endoplasmic reticulum (ER) stress, regulates the expression of factors that restore protein folding homeostasis. However, in the liver and kidney, ER stress also leads to lipid accumulation, accompanied at least in the liver by transcriptional suppress...
2017-06-23 | MTBLS472 | MetaboLights
MetabolomicsPodophyllotoxin-induced nephrotoxicity via the microbiota-gut-kidney axis in SD rats based on the toxicological evidence chain (TEC) concept
Podophyllotoxin (PPT) exhibits limited clinical utility due to its nephrotoxicity, and its underlying mechanisms remain poorly understood. This study employs the toxicological evidence chain (TEC) framework and integrated multi-omics analyses to investigate the potential involvement of the microbiot...
2026-06-25 | MTBLS14854 | MetaboLights
TranscriptomicsTranscription profiling of rat kidney tubules infected with uropathogenic E. coli to study early local bacterial inflammation
The transcriptome of early local kidney inflammation was profiled. Rat kidney tubules were injected with uropathogenic E. coli or PBS control. After incubation time, kidney samples were processed and transcription was assayed. Three rats were used per condition.
ORGANISM(S): Rattus norvegicus 
2010-04-14 | E-MEXP-2136 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of cultured rat primary proximal tubular cells (PTC) after isolation and differentiation
The aim of this study is to evaluate the transcripitomics changes during dedifferentiation up to 7 days in a transwell system of rat primary proximal tubular cell (PTC) cultures isolated from rat kidneys. Samples were taken from freshly isolated PTC (0 days) and at timeponts during PTC differentiati...
ORGANISM(S): Rattus norvegicus 
2024-06-30 | E-MTAB-13633 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat liver and kidney (F344 strain) following exposure to benzene, trichloroethylene, methyl mercury and their mixtures
The present research aimed to study the interaction of three chemicals, methyl mercury, benzene and trichloroethylene, on mRNA expression alterations in rat liver and kidney measured by microarray analysis. These compounds were selected on presumed different modes of action. The chemicals were admi...
ORGANISM(S): Rattus norvegicus 
2007-09-15 | E-TOXM-30 | biostudies-arrayexpress
TranscriptomicsGene Expression of Kidney from HSRA-S (congenital solitary kidney) and HSRA-C (two-kidney) using Rat Gene 1.1 ST Array [RaGene-1_1-st]
We recently developed a new model of renal agenesis [i.e., the heterogeneous stock derived model of unilateral renal agenesis, (HSRA)]. The HSRA model consistently exhibits unilateral renal agenesis ranging from 50-75% in each generation and is characterized by low nephron number, early kidney hyper...
ORGANISM(S): Rattus norvegicus 
2014-10-07 | E-GEOD-62092 | biostudies-arrayexpress
TranscriptomicsGene Expression Profiles of Transplanted Kidneys from Deceased Donors with Severe Acute Kidney Injury
One and four month formalin-fixed paraffin embedded biopsies from 48 kidney transplant recipients (24 AKI donors, 24 non-AKI) underwent global gene expression profiling using DNA microarrays (96 arrays). At one month, there were 898 differentially expressed genes in the AKI group (p-value <0.005; FD...
ORGANISM(S): Homo sapiens 
2015-05-22 | E-GEOD-61739 | biostudies-arrayexpress
TranscriptomicsMolecular changes in kidney allografts after simultaneous liver-kidney compared with solitary kidney transplantation
The aim of this study was to investigate correlations between early subclinical findings (10 and 90 day histology and gene expression data) and late outcomes (transplant glomerulopathy and graft loss) in positive crossmatch kidney transplants (+XMKTx). Our goal was threefold: first, to confirm that ...
ORGANISM(S): Homo sapiens 
2017-04-14 | E-GEOD-97780 | biostudies-arrayexpress
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