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ModelsKierzek2001_LacZ
An approximation to the Kierzek AM. et al. J Biol Chem. (2001) 276(11):8165-72 model of LacZ gene expression in E. coli. They use stochastic simulation and model cell growth. Despite these discrepancies, the continuous fixed size model is within a factor of 3 of their results. Parameter values ident...
2005-01-01 | MODEL4821294342 | BioModels
TranscriptomicsTranscription profiling of Streptomyces coelicolor wild type and phP-null mutants at different time points during phosphate starvation
S. coelicolor was grown in low-phosphate concentration R5 liquid medium which facilitated the transition to a phosphate starvation induced stationary phase and the subsequent induction of the PhoP regulon. Global gene expression profiling of a wild-type and a phoP-null mutant was performed using sam...
ORGANISM(S): Streptomyces coelicolor 
2012-08-30 | E-MAXD-51 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of Streptomyces coelicolor wild type and phP-null mutants during phosphate starvation to determine binding locations of PhoP
S. coelicolor was grown in low-phosphate concentration R5 liquid medium which facilitated the transition to a phosphate starvation induced stationary phase and the subsequent induction of the PhoP regulon. The genome wide binding locations of PhoP during phosphate starvation were determined by chrom...
ORGANISM(S): Streptomyces coelicolor 
2012-08-30 | E-MAXD-50 | biostudies-arrayexpress
ModelsBeste2007 - Genome-scale metabolic network of Mycobacterium tuberculosis (GSMN_TB)
Beste2007 - Genome-scale metabolic network of Mycobacterium tuberculosis (GSMN_TB) This model is described in the article: GSMN-TB: a web-based genome-scale network model of Mycobacterium tuberculosis metabolism. Beste DJ, Hooper T, Stewart G, Bonde B, Avignone-Rossa C, Bush...
2015-07-30 | MODEL1507180021 | BioModels
ModelsGupta2025 - Hepatic metabolism with PPARa regulation
New approach methodologies (NAMs) are advancing the reduction of animal testing by promoting human-relevant safety assessments across diverse applications, including cosmetics, pharmaceuticals, and environmental chemicals. Among these methodologies, computational models like quantitative systems tox...
2026-03-21 | MODEL2509090001 | BioModels
ModelsMaldonado2017 - Integration of Genome Scale Metabolic Networks and Gene Regulation of Metabolic Enzymes With Physiologically Based Pharmacokinetics
Example models of ongoing work on integration of PBPK, GSMNs, and metabolic gene regulation.
2021-11-05 | MODEL2111050001 | BioModels
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