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MetabolomicsX-ray Irradiation Suppresses Keloid Growth by Inducing G2/M Arrest via the Phytosphingosine-KIF20A Axis
Keloid radiotherapy is clinically effective but has an incomplete underlying molecular mechanism and limited accessibility; we used X-ray exposure to identify effector pathways replicating its antifibrotic benefits without further radiation. After collecting patient keloid samples, primary human kel...
2026-06-06 | MTBLS14461 | MetaboLights
ProteomicsIdentification of KIF20A binding partners using IP-mass spectrometry analysis
Breast cancer stem cells (BCSCs), known to fuel TNBC malignancy, are now being exploited as the vulnerability for TNBC treatment. In this study, we dissected the transcriptome of BCSCs and identified Kinesin Family Member 20A (KIF20A) as an essential gene for BCSC survival and TNBC tumorigenesis. To...
ORGANISM(S): Homo sapiens (Human) 
2025-09-30 | PXD060031 | Pride
Kif20a Ip-mass spectrometry Mda-mb-231 
GenomicsKIF20A/MKLP2 regulates the division modes of neural progenitor cells during cortical development
KIF20A/MKLP2 regulates the division modes of neural progenitor cells during cortical development
PRJNA427903 | ENA
GenomicsKIF20A promotes the development of soft tissue sarcoma by activating the PI3K-AKT signaling pathway
KIF20A promotes the development of soft tissue sarcoma by activating the PI3K-AKT signaling pathway
PRJNA588179 | ENA
TranscriptomicsKIF20A/MKLP2 regulates the division modes of neural progenitor cells during cortical development
Balanced symmetric and asymmetric divisions of neural progenitor cells (NPCs) are crucial for orderly progression of brain development, but the underlying mechanisms are not fully understood. Here, we report that mitotic kinesin KIF20A/MKLP2 interacts with RGS3 and plays a crucial role in controllin...
ORGANISM(S): Mus musculus 
2018-05-14 | GSE108624 | GEO
GenomicsIdentification of KIF20A as a vulnerability for breast cancer stem-like cells in triple negative breast cancer
Identification of KIF20A as a vulnerability for breast cancer stem-like cells in triple negative breast cancer
PRJNA1268475 | ENA
TranscriptomicsKIF20A promotes the development of soft tissue sarcoma by activating the PI3K-AKT signaling pathway
Soft tissue sarcoma (STS) is a group of malignancies that can appear in any part of the body. The prognosis of STS patients remains unsatisfactory, mainly due to metastasis and recurrence. Upregulation of KIF20A is associated with poor prognosis of STS patients, but its downstream mechanism is unkno...
ORGANISM(S): Homo sapiens 
2020-11-23 | GSE140074 | GEO
TranscriptomicsIdentification of KIF20A as a vulnerability for breast cancer stem-like cells in triple negative breast cancer
Triple-negative breast cancer (TNBC), being both aggressive and highly lethal, poses a significant challenge in terms of treatment. Its heterogeneity and lack of hormone receptors or HER2 expression further restrict the availability of targeted therapy. Breast cancer stem cells (BCSCs), known to fue...
ORGANISM(S): Homo sapiens 
2025-10-09 | GSE298177 | GEO
TranscriptomicsIdentification and validation of KIF20A for predicting prognosis and treatment outcomes in patients with breast cancer
In the study, we analyzed six pairs of differentially expressed genes between breast cancer tissues and their corresponding adjacent normal tissues, identifying KIF20A as significantly upregulated in breast cancer. Further functional analyses confirmed that KIF20A is a central regulator within the b...
ORGANISM(S): Homo sapiens 
2025-10-24 | GSE280284 | GEO
GenomicsIdentification and validation of KIF20A for predicting prognosis and treatment outcomes in patients with breast cancer
Identification and validation of KIF20A for predicting prognosis and treatment outcomes in patients with breast cancer
PRJNA1177580 | ENA
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