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TranscriptomicsTranscription profiling of human dendritic cells from PLOSL patients show abnormalities in pathways of actin bundling and immune response
This study was aimed to identify pathways associated with loss-of-function of the DAP12/TREM2 receptor complex and thus gain insight into pathogenesis of PLOSL (polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy). Transcript profiles of PLOSL patients' DCs showed differenti...
ORGANISM(S): Homo sapiens 
2008-11-06 | E-GEOD-3624 | biostudies-arrayexpress
TranscriptomicsGenome-wide expression analysis of Dap12 (Tyrobp)-deficient mouse brain and microglial cells
This SuperSeries is composed of the following subset Series: GSE9043: Dap12 microglia GSE9061: Dap12-deficient mouse brain (1 month) Keywords: SuperSeries Refer to individual Series
ORGANISM(S): Mus musculus 
2011-08-23 | E-GEOD-9083 | biostudies-arrayexpress
TranscriptomicsWhite-to-brown metabolic conversion of human adipocytes by JAK inhibition
The rising incidence of obesity and related disorders such as diabetes and heart disease has focused considerable attention on the discovery of novel therapeutics. One promising approach has been to increase the number or activity of brown-like adipocytes in white adipose depots, as this has been...
ORGANISM(S): Homo sapiens 
2014-10-31 | E-GEOD-57896 | biostudies-arrayexpress
TranscriptomicsDap12 microglia
Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL) is an inherited brain and bone disease. It manifests as dementia and bone fractures. The PLOSL phenotype is caused by loss-of-function mutations in one of the two genes encoding the components of the DAP12/TREM2 rec...
ORGANISM(S): Mus musculus 
2011-08-23 | E-GEOD-9043 | biostudies-arrayexpress
TranscriptomicsDap12-deficient mouse brain (1 month)
Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL) is an inherited brain and bone disease. It manifests as dementia and bone fractures. The PLOSL phenotype is caused by loss-of-function mutations in one of the two genes encoding the components of the DAP12/TREM2 rec...
ORGANISM(S): Mus musculus 
2011-08-23 | E-GEOD-9061 | biostudies-arrayexpress
TranscriptomicsModeling the Neuropathology of Tuberous Sclerosis with Human Stem Cells Reveals a Role for Inflammation and Angiogenic Growth Factors [Treatment]
Tuberous sclerosis complex (TSC) is a rare genetic disease characterized by mTOR hyperfunction induced benign tumor growths in multiple organs and neurological symptoms. Because the molecular pathology is highly complex and the etiology poorly understood we employed a defined human neuronal model wi...
ORGANISM(S): Homo sapiens 
2016-07-25 | E-GEOD-78960 | biostudies-arrayexpress
TranscriptomicsModeling the Neuropathology of Tuberous Sclerosis with Human Stem Cells Reveals a Role for Inflammation and Angiogenic Growth Factors [Cell Model]
Tuberous sclerosis complex (TSC) is a rare genetic disease characterized by mTOR hyperfunction induced benign tumor growths in multiple organs and neurological symptoms. Because the molecular pathology is highly complex and the etiology poorly understood we employed a defined human neuronal model wi...
ORGANISM(S): Homo sapiens 
2016-07-25 | E-GEOD-78959 | biostudies-arrayexpress
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