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TranscriptomicsExpression data from Bmi1 mutant versus wild-type lung cells
Bmi1 is an important stem cell regulator in multiple tissues, including the lung. We used microarrays to analyze the dysregulation of gene expression in the absence of Bmi1 in the lung, to identify pathways important in Bmi1-dependent lung stem cell regulation Primary lung cells (CD31-negative, CD45...
ORGANISM(S): Mus musculus 
2011-09-01 | E-GEOD-30852 | biostudies-arrayexpress
TranscriptomicsGene expression by Retinoic Acid in mouse Dendritic Cells
The purpose of this study was to determine and clarify the retinoic effect on the gene expression profile for mouse dendritic cells. Dendritic cells were prepared from marrow cells by culturing them for 10 days with GM-CSF (20 ng/ml). These cells were cultured with the following reagents from the ...
ORGANISM(S): Mus musculus 
2013-02-26 | E-GEOD-34324 | biostudies-arrayexpress
TranscriptomicsChanges in Global Gene Expression Associated with 3D Structure of Tumors: an ex vivo Matrix-Free Mesothelioma Spheroid Model
Tumor microenvironments present significant barriers to anti-tumor agents. Molecules involved in multicellular tumor microenvironments, however, are difficult to study ex vivo. Here, we generated a matrix-free tumor spheroid model using the NCI-H226 mesothelioma cell line and compared the gene expre...
ORGANISM(S): Homo sapiens 
2012-06-20 | E-GEOD-37629 | biostudies-arrayexpress
TranscriptomicsEctopic expression of MYB46 identifies transcriptional regulatory genes in secondary wall biosynthesis in Arabidopsis
MYB46 functions as a transcriptional switch that turns on the genes necessary for secondary wall biosynthesis. Elucidating the transcriptional regulatory network immediately downstream of MYB46 is crucial to our understanding of the molecular and biochemical processes involved in the biosynthesis an...
ORGANISM(S): Arabidopsis thaliana 
2010-05-27 | E-GEOD-16143 | biostudies-arrayexpress
TranscriptomicsIdentification of Biofilm Inhibitors from Streptomyces Strains for Reducing Pseudomonas aeruginosa Biofilm Formation
Biofilms are ubiquitous in natural, medical, and engineering environments. While most antibiotics that primarily aim to inhibit cell growth may result in bacterial drug resistance, biofilm inhibitors do not affect cell growth and there is less chance of developing resistance. This work sought to id...
ORGANISM(S): Pseudomonas aeruginosa 
2013-03-21 | E-GEOD-28194 | biostudies-arrayexpress
TranscriptomicsRIP-chip analysis of the C. elegans GLD-2 and RNP-8 protein
C. elegans GLD-2 forms an active PAP with multiple RNA-binding partners to regulate diverse aspects of germline and early embryonic development. One GLD-2 partner, RNP-8, was previously shown to influence oocyte fate specification. To identify transcripts selectively associated with both GLD-2 and R...
ORGANISM(S): Caenorhabditis elegans 
2010-09-21 | E-GEOD-23843 | biostudies-arrayexpress
TranscriptomicsTemporal Profiling of Rat Transcriptomes in Retinol-Replenished Vitamin A-Deficient Testis
We used microarrays to examine the temporal transcriptome changes of vitamin a deficient rats testes replenished with retinol 20-day old rats were put on a vitamin A deficient diet, after nine weeks the animals were treated with retinol for 0-(VAD), 4-, 8-, 24-hr to determine the global transcriptom...
ORGANISM(S): Rattus norvegicus 
2009-02-27 | E-GEOD-14962 | biostudies-arrayexpress
TranscriptomicsAuxin stimulates brassinosteroid biosynthesis in Arabidopsis roots
We found that auxin stimulates gene expression of DWF4, which encodes a rate-dertermining step in brassinosteroid biosynthesis pathways. This increased gene expressioin subsequently led to elevation of the biosynthetic flux in Arabidopsis roots. To determine the list of genes that are regulated by a...
ORGANISM(S): Arabidopsis thaliana 
2011-02-15 | E-GEOD-12964 | biostudies-arrayexpress
UnknownHepatic transcriptional profile reveals the role of diet and genetic backgrounds on metabolic traits in female progenitor strains of the Collaborative Cross.
Not available
S-EPMC8424536 | biostudies-literature
UnknownObesogenic and diabetic effects of CD44 in mice are sexually dimorphic and dependent on genetic background.
Not available
S-EPMC8996418 | biostudies-literature
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