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TranscriptomicsGenome-wide polysome analysis in poly(I:C)-treated WT and Oasl1-/- BMDM.
OASL1 is a novel translation inhibitor for the type I IFN master transcription factor IRF7. To examine whether OASL1 specifically inhibit IRF7 translation, we used a genome-wide gene expression microarray to screen for the polysome-associated mRNAs more enriched in the OASL1 KO BMDMs. The microarray...
ORGANISM(S): Mus musculus 
2013-02-17 | E-GEOD-41787 | biostudies-arrayexpress
TranscriptomicsExpression data from the comparison between poly(I:C)-treated WT and Oasl1-/- BMDMs
Oasl1-/- BMDMs express more type I IFN upon poly(I:C) treatment. Because OASL1 seems to rather specifically suppress the type I IFN expression, we tried to address the specificity by determining the defects associated with the Oasl1 mutation using genome-wide gene expression microarray analysis unde...
ORGANISM(S): Mus musculus 
2013-02-17 | E-GEOD-41788 | biostudies-arrayexpress
MetabolomicsDiel metabolomics analysis of a hot spring chlorophototrophic microbial mat leads to new hypotheses of community member metabolisms
Dynamic environmental factors such as light, nutrients, salt, and temperature continuously affect chlorophototrophic microbial mats, requiring adaptive and acclimative responses to stabilize composition and function. Quantitative metabolomics analysis can provide insights into metabolite dynamics fo...
2024-02-23 | MTBLS187 | MetaboLights
TranscriptomicsTranscriptional effects of I-PpoI induced DNA double strand breaks in mouse lymphocytes
DNA double-strand breaks (DSBs) and their repair can cause extensive epigenetic changes. As a result, DSBs have been proposed to promote transcriptional and, ultimately, physiological dysfunction via both cell-intrinsic and cell-non-autonomous pathways. Studying the consequences of DSBs in higher or...
ORGANISM(S): Mus musculus 
2016-01-04 | E-GEOD-74855 | biostudies-arrayexpress
MetabolomicshRUV: Hierarchical approach to removal of unwanted variation for large-scale metabolomics data
Liquid chromatography-mass spectrometry-based metabolomics studies are increasingly applied to large population cohorts, which run for several weeks or even years in data acquisition. This inevitably introduces unwanted intra- and inter-batch variations over time that can overshadow true biological ...
2021-07-05 | MTBLS2483 | MetaboLights
UnknownProgesterone inactivation in decidual stromal cells: A mechanism for inflammation-induced parturition.
Not available
S-EPMC11194587 | biostudies-literature
GenomicsEffect of splicing on histone H3 K36 methylation
Histone H3 K36me3 and RNA pol II were localized by ChIP before and after inhibition of splicing by spliceostatin for 12 hr. Total matched reads for the control and SSA treated Hela samples were 11.6 and 8.2 million for anti-H3K36me3 and 6.6 and 5.0 million for anti-pol II. ChIP-seq of histone H3 K36...
ORGANISM(S): Homo sapiens 
2011-09-05 | E-GEOD-30895 | biostudies-arrayexpress
UnknownClinical application of genomic profiling to find druggable targets for adolescent and young adult (AYA) cancer patients with metastasis.
Not available
S-EPMC4772349 | biostudies-literature
UnknownBeyond the Golden Hour: Treating Acute Stroke in the Platinum 30 Minutes.
Not available
S-EPMC9329219 | biostudies-literature
UnknownMercaptopurine Ingestion Habits, Red Cell Thioguanine Nucleotide Levels, and Relapse Risk in Children With Acute Lymphoblastic Leukemia: A Report From the Children's Oncology Group Study AALL03N1.
Not available
S-EPMC5455766 | biostudies-literature
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