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UnknownBuspirone alleviates anxiety, depression, and colitis; and modulates gut microbiota in mice.
Not available
S-EPMC7969772 | biostudies-literature
MetabolomicsMapping the metabolism of five amino acids in bloodstream form Trypanosoma brucei using U-13C-labelled substrates and LC–MS
The metabolism of the parasite Trypanosoma brucei has been the focus of numerous studies since the 1940s. Recently it was shown, using metabolomics coupled with heavy-atom isotope labelled glucose, that the metabolism of the bloodstream form parasite is more complex than previously thought. The pres...
2019-06-24 | MTBLS624 | MetaboLights
TranscriptomicsA dysregulated Acetyl/SUMO switch of FXR promotes hepatic inflammation in obesity
Acetylation of transcriptional regulators is normally dynamically regulated by nutrient status but is often persistently elevated in nutrient-excessive obesity conditions. We investigated the functional consequences of such aberrantly elevated acetylation of the nuclear receptor FXR as a model. Prot...
ORGANISM(S): Mus musculus 
2014-10-17 | E-GEOD-62414 | biostudies-arrayexpress
Genomicsena-DATASET-KAIST-03-05-2017-03:08:17:539-449 - samples
This dataset includes the high-throughput sequencing data from a study entitled "Clonal History and Genetic Predictors of Transformation into Small Cell Carcinomas from Lung Adenocarcinomas". Whole-genome sequencing libraries were generated by PCR-free methods, and sequencing run was made in HiSeq X...
EGAD00001003315 | EGA
GenomicsEvolutionary Genome Analysis of Transformation into Small Cell Carcinomas from Lung Adenocarcinomas
Anecdotal case have been reported lung adenocarcinoma could occasionally transform into small cell carcinoma. Most of the reported cases were EGFR-mutant lung adenocarcinomas that transform into small cell carcinoma during EGFR tyrosine kinase inhibitor treatment. However, some cases also indicate l...
EGAS00001001757 | EGA
TranscriptomicsMethylation of Polycomb target genes in intestinal cancer is mediated by inflammation
Using glutathione peroxidase, Gpx1 and Gpx2, double knockout (Gpx1/2-KO) mice as a model of inflammatory bowel disease predisposing to intestinal cancer, we analyzed genome-wide DNA methylation and chromatin changingM-bM-^@M-^Ys in the mouse ileum during chronic inflammation, aging and cancer. We fo...
ORGANISM(S): Mus musculus 
2008-12-31 | E-GEOD-12315 | biostudies-arrayexpress
MetabolomicsMetabolomics guides rational development of a simplified cell culture medium for drug screening against Trypanosoma brucei
In vitro culture methods underpin many experimental approaches to biology and drug discovery. The modification of established cell culture methods to be more biologically relevant, or to optimise growth, is traditionally a laborious task. Emerging metabolomics technology enables rapid evaluation of ...
2015-05-14 | MTBLS49 | MetaboLights
UnknownClinical Outcomes and Response to Vericiguat According to Index Heart Failure Event: Insights From the VICTORIA Trial.
Not available
S-EPMC7666431 | biostudies-literature
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