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GenomicsEffect of splicing on histone H3 K36 methylation
Histone H3 K36me3 and RNA pol II were localized by ChIP before and after inhibition of splicing by spliceostatin for 12 hr. Total matched reads for the control and SSA treated Hela samples were 11.6 and 8.2 million for anti-H3K36me3 and 6.6 and 5.0 million for anti-pol II. ChIP-seq of histone H3 K36...
ORGANISM(S): Homo sapiens 
2011-09-05 | E-GEOD-30895 | biostudies-arrayexpress
TranscriptomicsBudding yeast mRNA poly(A) site mapping
The yeast mRNA export adaptor Yra1 binds the Pcf11 subunit of cleavage-polyadenylation factor CF1A linking export to 3'-end formation. We found a surprising consequence of this interaction is that Yra1 influences cleavage-polyadenylation. Yra1 competes with the CF1A subunit, Clp1, for binding to Pcf...
ORGANISM(S): Saccharomyces cerevisiae 
2011-09-24 | E-GEOD-30703 | biostudies-arrayexpress
TranscriptomicsBudding yeast RNA polymerase II CTD phosphorylation and transcription termination factor localization
Whole genome analysis of total RNA pol II, Ser2-, Ser5- and Ser7-phosphorylated RNA pol II, in WT and mutants of the C-terminal domain (CTD) kinases Ctk1 and Kin28, and localization of the termination factors Pcf11, Nrd1 and Rat1. ChIP-chip using ligation-mediated PCR-amplified material hybridized t...
ORGANISM(S): Saccharomyces cerevisiae 
2010-09-15 | E-GEOD-23960 | biostudies-arrayexpress
TranscriptomicsBudding yeast mRNA export and processing factor localization
The yeast mRNA export adaptor Yra1 binds the Pcf11 subunit of cleavage-polyadenylation factor CF1A linking export to 3'-end formation. We found a surprising consequence of this interaction is that Yra1 influences cleavage-polyadenylation. Yra1 competes with the CF1A subunit, Clp1, for binding to Pcf...
ORGANISM(S): Saccharomyces cerevisiae 
2011-09-24 | E-GEOD-30705 | biostudies-arrayexpress
TranscriptomicsPre-mRNA Splicing is Facilitated by an Optimal RNA Polymerase II Elongation Rate
Transcription and pre-mRNA alternative splicing was analyzed by in isogenic human HEK293 cell lines that inducibly express a-amanitin resistant mutants of the RNA polymerase II large subunit with slow and fast elongation rates. Alternative splicing was analyzed by, RNA-seq and RASL-seq of polyA+ RN...
ORGANISM(S): Homo sapiens 
2014-11-25 | E-GEOD-63375 | biostudies-arrayexpress
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